Academic Journal
Genetic risk factors and causal associations with sudden cardiac arrest: A Mendelian randomization study.
| Τίτλος: | Genetic risk factors and causal associations with sudden cardiac arrest: A Mendelian randomization study. |
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| Συγγραφείς: | Wu H; Department of Obstetrics and Gynecology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China., Hu F; Department of Epidemiology and Biostatistics, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China., Liu L; Department of Epidemiology and Biostatistics, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China., Wu M; Department of Anesthesia, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China., Lin Y; Department of Obstetrics and Gynecology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China., Wang M; Department of Epidemiology and Biostatistics, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, China. |
| Πηγή: | Medicine [Medicine (Baltimore)] 2026 Oct 09; Vol. 105 (41), pp. e50928. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| Ιατρικοί όροι (MeSH): | Death, Sudden, Cardiac*/etiology , Death, Sudden, Cardiac*/epidemiology , Mendelian Randomization Analysis* , Genetic Predisposition to Disease*, Blood Pressure/genetics ; Cholesterol/blood ; Humans ; Genome-Wide Association Study ; Risk Factors ; Polymorphism, Single Nucleotide |
| Περίληψη: | Sudden cardiac arrest (SCA) is a major cause of mortality, with complex etiology involving multiple genetic and environmental factors. In this study, we aimed to identify genetic risk factors for SCA and evaluate their causal associations using Mendelian randomization (MR) analysis. We retrieved summarized genome-wide association study data for various exposures and the SCA outcome from public databases. Four MR methods, including inverse variance weighted (IVW), Egger, weighted median, and weighted mode, were applied to estimate causal effects. All MR methods revealed significant positive causal associations with SCA from diastolic blood pressure (IVW: b = 0.09, P = 5 × 10-18), systolic blood pressure (IVW: b = 0.06, P = 5 × 10-25), and total cholesterol levels (IVW: b = 0.28, P = 4 × 10-3). No consistent causal link was found for heart rate, body mass index, type 2 diabetes, and certain cardiac electrophysiological factors (P values for all 4 MR methods were not consistently below the significance level of .05). These findings provide insights into the genetic architecture of SCA and highlight potential targets for risk stratification and preventive strategies. (Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, LLC.) |
| Competing Interests: | The authors have no conflicts of interest to declare. |
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| Contributed Indexing: | Keywords: Mendelian randomization; causal inference; genome-wide association study; risk factor; sudden cardiac arrest |
| Substance Nomenclature: | 97C5T2UQ7J (Cholesterol) |
| Entry Date(s): | Date Created: 20261009 Date Completed: 20261009 Latest Revision: 20261009 |
| Update Code: | 20261010 |
| DOI: | 10.1097/MD.0000000000050928 |
| PMID: | 42854003 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1536-5964 |
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| DOI: | 10.1097/MD.0000000000050928 |