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Early life stress caused glucose homeostasis impairment and anxiety-like behavior along with oxidative stress in adolescent male rat offspring: Protective effect of saffron extract.

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Τίτλος: Early life stress caused glucose homeostasis impairment and anxiety-like behavior along with oxidative stress in adolescent male rat offspring: Protective effect of saffron extract.
Συγγραφείς: Shirzadeh Barough S; Neurophysiology Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Saeidi B; Foot and Mouth Disease Reference Laboratory, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran., Binayi F; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Salimi M; Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.; Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Siavoshi F; Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Karbaschi R; Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hedayati M; Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Zardooz H; Neurophysiology Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Πηγή: PloS one [PLoS One] 2026 Oct 07; Vol. 21 (10), pp. e0359395. Date of Electronic Publication: 2026 Oct 07 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Imprint Name(s): Original Publication: San Francisco, CA : Public Library of Science
Ιατρικοί όροι (MeSH): Crocus*/chemistry , Plant Extracts*/pharmacology , Oxidative Stress*/drug effects , Anxiety*/drug therapy , Anxiety*/metabolism , Anxiety*/etiology , Stress, Psychological*/metabolism , Glucose*/metabolism, Homeostasis/drug effects ; Blood Glucose/metabolism ; Corticosterone/blood ; Insulin/blood ; Behavior, Animal/drug effects ; Glutathione/metabolism ; Malondialdehyde/metabolism ; Catalase/metabolism ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/drug effects ; Animals ; Male ; Rats, Wistar ; Rats
Περίληψη: Early life stress (ELS) significantly contributes to metabolic and psychological disorders by triggering oxidative stress and disrupting the hypothalamic-pituitary-adrenal (HPA) axis. This research examined ELS effects on redox status, along with anxiety-like behavior, in adolescent male Wistar rats, also assessing saffron (Crocus sativus L.) extract's potential benefits. Rats were exposed to foot shock stress from postnatal days 15-19, with treatment groups receiving saline or saffron extract (10 mg/kg) via intraperitoneal injection. Control groups were maintained without stress exposure. Elevated Plus Maze (EPM) and Open Field Test (OFT) were used to evaluate anxiety-like behaviors. Corticosterone, glucose, and insulin levels, oxidative stress markers [malondialdehyde (MDA), glutathione (GSH), and catalase activity] in the plasma, pancreas, and amygdala were determined, and the HOMA-β index was estimated. Saffron extract markedly restored ELS effects by reducing fasting plasma glucose and corticosterone levels, while increasing insulin levels and the HOMA-β index in adolescent offspring. Additionally, saffron extract inhibited oxidative stress, evidenced by reduced MDA, normalized catalase activity, and augmented GSH levels in the plasma, pancreas, and amygdala. Behaviorally, saffron extract-treated rats exhibited diminished anxiety-like behaviors, characterized by increased time spent in the open arms of the EPM and the center zone in the OFT. This study suggests that ELS induces disturbances in glucose metabolism and anxiety-like behavior, accompanied by oxidative stress and increased HPA axis activity. The protective role of saffron extract underscores its capability to serve as a medicinal compound for preventing and treating stress-induced metabolic and anxiety disorders.
(Copyright: © 2026 Shirzadeh Barough et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Competing Interests: The authors have declared that no competing interests exist.
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Substance Nomenclature: 0 (Plant Extracts)
0 (Blood Glucose)
W980KJ009P (Corticosterone)
0 (Insulin)
GAN16C9B8O (Glutathione)
IY9XDZ35W2 (Glucose)
4Y8F71G49Q (Malondialdehyde)
EC 1.11.1.6 (Catalase)
Entry Date(s): Date Created: 20261007 Date Completed: 20261007 Latest Revision: 20261009
Update Code: 20261009
PubMed Central ID: PMC13645216
DOI: 10.1371/journal.pone.0359395
PMID: 42842729
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1932-6203
DOI:10.1371/journal.pone.0359395