Academic Journal
Diversity and spatial segregation of TRP channels in the closest relatives of animals.
| Τίτλος: | Diversity and spatial segregation of TRP channels in the closest relatives of animals. |
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| Συγγραφείς: | Mannsåker S; Michael Sars Centre, University of Bergen, Bergen 5006, Norway., Burkhardt P; Michael Sars Centre, University of Bergen, Bergen 5006, Norway., Colgren J; Michael Sars Centre, University of Bergen, Bergen 5006, Norway. |
| Πηγή: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Oct 13; Vol. 123 (41), pp. e2625484123. Date of Electronic Publication: 2026 Oct 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : National Academy of Sciences |
| Ιατρικοί όροι (MeSH): | Transient Receptor Potential Channels*/genetics , Transient Receptor Potential Channels*/metabolism , Choanoflagellata*/genetics , Choanoflagellata*/metabolism, Animals ; Phylogeny ; Evolution, Molecular ; Biological Evolution |
| Περίληψη: | Sensory systems, built around specialized cell types, are central to how animals perceive and respond to their environments. However, the evolutionary origin of these systems remains unclear. Here, we show that choanoflagellates, the sister group of animals, possess remarkably diverse repertoires of transient receptor potential (TRP) channels, an ancient superfamily of sensory ion channels. Comparative analyses indicate that most major animal TRP channel families predate the origin of animals and reveal extensive radiations of the TRPM and TRPW families within choanoflagellates, with the latter family likely being lost in the animal lineage. Furthermore, in the choanoflagellate model Salpingoeca rosetta, TRPA, TRPC and TRPV occupy discrete microdomains within the collar complex, a key interface for environmental sensing and feeding. We propose that the evolution of animal sensory systems involved both expansion and reorganization of this ancestral repertoire, with subcellular patterning in unicellular organisms representing a precursor to cell-type specialization in multicellular animals. |
| Competing Interests: | Competing interests statement:The authors declare no competing interest. |
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| Grant Information: | 234817 Norwegian Research Council |
| Contributed Indexing: | Keywords: TRP channels; TRPW; choanoflagellates; origin of animals; sensory evolution |
| Substance Nomenclature: | 0 (Transient Receptor Potential Channels) |
| Entry Date(s): | Date Created: 20261007 Date Completed: 20261007 Latest Revision: 20261016 |
| Update Code: | 20261016 |
| PubMed Central ID: | PMC13663828 |
| DOI: | 10.1073/pnas.2625484123 |
| PMID: | 42842415 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1091-6490 |
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| DOI: | 10.1073/pnas.2625484123 |