Academic Journal
Prevalence of Arthritis in Systemic Lupus Erythematosus in Pakistan: A Systematic Review and Meta-analysis.
| Τίτλος: | Prevalence of Arthritis in Systemic Lupus Erythematosus in Pakistan: A Systematic Review and Meta-analysis. |
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| Συγγραφείς: | Khan MI; Division of Biostatistics, Department of Population Health, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; College of Science and Health Professions (COSHP), King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia., Qureshi H; College of Management, Shenzhen University, Shenzhen, China. humiimran1745@yahoo.com., Hassan F; Iqra National University, Swat Campus, Swat, Khyber Pakhtunkhwa, Pakistan., Akhtar S; Department of Statistics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia., Ahmad S; Data Science and Blockchain Laboratory, College of Computer and Information Sciences, Prince Sultan University, Riyadh, 11586, Saudi Arabia., Ateya AA; Data Science and Blockchain Laboratory, College of Computer and Information Sciences, Prince Sultan University, Riyadh, 11586, Saudi Arabia., El-Affendi MA; Data Science and Blockchain Laboratory, College of Computer and Information Sciences, Prince Sultan University, Riyadh, 11586, Saudi Arabia. |
| Πηγή: | Journal of epidemiology and global health [J Epidemiol Glob Health] 2026 Sep 30; Vol. 16 (1). Date of Electronic Publication: 2026 Sep 30. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Switzerland NLM ID: 101592084 Publication Model: Electronic Cited Medium: Internet ISSN: 2210-6014 (Electronic) Linking ISSN: 22106006 NLM ISO Abbreviation: J Epidemiol Glob Health Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [Cham] : Springer Original Publication: Amsterdam : Elsevier, [2011]- |
| Ιατρικοί όροι (MeSH): | Lupus Erythematosus, Systemic*/epidemiology , Lupus Erythematosus, Systemic*/complications , Arthritis*/epidemiology , Arthritis*/etiology, Pakistan/epidemiology ; Humans ; Prevalence |
| Περίληψη: | Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations that significantly affect patients' quality of life. Arthritis is one of the most common and disabling manifestations of SLE. This study aimed to provide a comprehensive estimate of the prevalence of arthritis among patients with SLE in Pakistan and to evaluate regional and temporal variations. Methods: Two independent reviewers selected eligible studies, extracted the data, and assessed the risk of bias. A random-effects meta-analysis was performed to account for between-study heterogeneity. Subgroup analyses and meta-regression were conducted to explore potential sources of study-level variation. Results: A total of 10 studies involving 1,292 participants were included in the meta-analysis. The pooled prevalence of arthritis among patients with SLE was 60.68% (95% CI: 46.41%-74.08%). Subgroup analysis showed that the highest prevalence was observed in Khyber Pakhtunkhwa (KP) (78.13%; 95% CI: 74.83%-81.11%), followed by Punjab (58.94%; 95% CI: 38.19%-78.15%) and Sindh (57.28%; 95% CI: 29.43%-82.82%). Studies published after 2010 reported a higher pooled prevalence (67.89%; 95% CI: 54.47%-79.95%) than those published before 2010 (42.11%; 95% CI: 34.74%-49.67%). Conclusion: The high prevalence of arthritis among patients with SLE in Pakistan highlights the need for improved screening, early diagnosis, and effective management strategies to reduce disease burden and improve patient outcomes. Prospero Registration Number: This systematic review and meta-analysis was registered with PROSPERO (CRD42023420108) on May 1st, 2023. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics Approval and Consent to Participate: Not applicable. Consent for Publication: Not applicable. |
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| Contributed Indexing: | Keywords: Arthritis; Meta-analysis; Pakistan; Prevalence; Systematic Review; Systemic Lupus Erythematosus |
| Entry Date(s): | Date Created: 20261007 Date Completed: 20261007 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| PubMed Central ID: | PMC13646219 |
| DOI: | 10.1007/s44197-026-00644-6 |
| PMID: | 42842145 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2210-6014 |
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| DOI: | 10.1007/s44197-026-00644-6 |