Association between diabetes mellitus and short-term outcomes after transsphenoidal surgery for pituitary tumor: Evidence from the Taiwan Pituitary Tumor Registry 2009-2019.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Association between diabetes mellitus and short-term outcomes after transsphenoidal surgery for pituitary tumor: Evidence from the Taiwan Pituitary Tumor Registry 2009-2019.
Συγγραφείς:	Kuo YH; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan., Chen YY; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan., Fu KH; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan., Yang CH; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan., Chen PY; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Yan JL; Department of Neurosurgery, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. color_genie@hotmail.com.; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. color_genie@hotmail.com.
Πηγή:	Endocrine [Endocrine] 2026 Oct 06; Vol. 91 (1). Date of Electronic Publication: 2026 Oct 06.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE
Imprint Name(s):	Publication: Feb. 1996- : Totowa, NJ : Humana Press Original Publication: Houndsmills, Basingstoke, Hants, UK : Macmillan Press, c1994-
Ιατρικοί όροι (MeSH):	Pituitary Neoplasms/surgery , Pituitary Neoplasms/epidemiology , Pituitary Neoplasms/complications , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Diabetes Mellitus/epidemiology, Taiwan/epidemiology ; Length of Stay/statistics & numerical data ; Patient Readmission/statistics & numerical data ; Humans ; Female ; Male ; Middle Aged ; Registries ; Retrospective Studies ; Adult ; Treatment Outcome ; Aged
Περίληψη:	Purpose: Diabetes mellitus (DM) may affect postoperative recovery, but evidence in pituitary tumor surgery remains limited. We investigated the association between DM and short-term outcomes after transsphenoidal surgery for pituitary tumors. Methods: We retrospectively analyzed adults in the Taiwan Pituitary Tumor Registry who underwent transsphenoidal surgery for benign pituitary tumors between 2009 and 2019. Patients were categorized into DM and non-DM groups. Associations between DM, prolonged length of hospital stays (LOS), 14-day readmission rate, and complications were determined using regression analyses. Tumor-type stratified analyses and receiver operating characteristic (ROC) analyses of glycated hemoglobin (HbA1c), fasting glucose, and random glucose were also performed. Results: Data of 970 patients were analyzed, of whom 144 (15%) had DM. DM was not significantly associated with prolonged LOS or 14-day readmission, but was significantly associated with higher odds of CSF leak (adjusted odds ratio [aOR] = 3.35, 95% confidence interval [CI]: 1.18-9.51, p = 0.023) and antibiotic use for ≥ 7 days (aOR = 5.41, 95% CI: 1.13-25.87, p = 0.034) in age-adjusted analysis. In the non-functioning tumor subgroup, the association with antibiotic use for ≥ 7 days persisted (aOR 7.37, 95% CI 1.46-37.12), whereas the association with CSF leak was not statistically significant. Among patients with DM and non-functioning tumors, glycemic markers showed apparent discrimination for postoperative infection and CSF leak, with area under the curve values ranging from 0.83 to 0.93. Conclusions: DM was associated with selected short-term complications after transsphenoidal surgery, particularly CSF leak and prolonged antibiotic use. These exploratory findings require confirmation in larger prospective studies with comprehensive surgical data. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests:	Declarations. Competing interests: The authors declare no competing interests.
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Contributed Indexing:	Keywords: Complication; Diabetes mellitus (DM); Pituitary tumor; Taiwan Pituitary Tumor Registry (TPTR); Transsphenoidal surgery (TSS)
Entry Date(s):	Date Created: 20261006 Date Completed: 20261006 Latest Revision: 20261010
Update Code:	20261010
DOI:	10.1007/s12020-026-04785-3
PMID:	42836901
Βάση Δεδομένων:	MEDLINE

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Περιγραφή
ISSN:	1559-0100
DOI:	10.1007/s12020-026-04785-3