Academic Journal
Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.
| Τίτλος: | Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine. |
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| Συγγραφείς: | Zhou S; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Tan J; West China School of Nursing, Sichuan University, Chengdu, China., Li X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Ran Z; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., He J; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Li Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Yuan X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Hu Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Chen M; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Dai Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China., Wang X; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Liu X; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Li R; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Xu Y; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China., Cheng G; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China. gcheng@scu.edu.cn.; West China School of Nursing, Sichuan University, Chengdu, China. gcheng@scu.edu.cn.; Children's Medicine Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. gcheng@scu.edu.cn.; West China School of Public Health and West China Fourth Hospital, West China Second University Hospital, Sichuan University, 16 Renminnan Road 3rd Section, Chengdu, 610041, China. gcheng@scu.edu.cn., Xiong J; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; Health Promotion and Food Nutrition & Safety Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; Occupational Health and Occupational Medicine Key Laboratory of Sichuan Provincial Health Commission, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; Molecular Toxicology Key Laboratory of Sichuan Provincial Education Office, West ChinaSchool of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. jzx0004@tigermail.auburn.edu.; West China School of Public Health and West China Fourth Hospital, West China Second University Hospital, Sichuan University, 16 Renminnan Road 3rd Section, Chengdu, 610041, China. jzx0004@tigermail.auburn.edu. |
| Πηγή: | Functional & integrative genomics [Funct Integr Genomics] 2026 Oct 06; Vol. 26 (1). Date of Electronic Publication: 2026 Oct 06. |
| Τύπος έκδοσης: | Journal Article; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer, c2000- |
| Ιατρικοί όροι (MeSH): | Taurine*/blood , Taurine*/genetics , Genome-Wide Association Study*, Humans ; Polymorphism, Single Nucleotide ; Linkage Disequilibrium |
| Περίληψη: | Taurine is a semiessential micronutrient critical to many biological processes. However, the genetic variation and the relationships between circulating taurine and human health are unclear. Here, we conducted the largest genome-wide meta-analysis to date, integrating summary statistics from five publicly available independent genome-wide association studies (GWAS) on circulating taurine levels in 36,490 European individuals. We employed LiftOver to harmonize genomic coordinates across the summary statistics derived from five large European cohorts with plasma taurine measurements, followed by a comprehensive genome-wide meta-analysis of both common and rare genetic variants. We utilized functional mapping and annotation and functional annotation of variants to identify genomic loci and variants and estimated global and local single-nucleotide polymorphism heritability using linkage disequilibrium score regression. In our study, we identified six common and two rare variant loci associated with circulating taurine and prioritized novel taurine-associated genes outside of the taurine transporter (SLC6A13) related to glutathione metabolism and neurotransmitter transport using an integrative pipeline. We used genetic proxies of circulating taurine to assess genetically supported putative causal associations on more than 17,000 clinical phenotypes via a phenome-wide Mendelian randomization analysis and demonstrated that genetically predicted circulating taurine shows evidence consistent with potential causal impacts on cancers, hypertension, neurodevelopment, abundance of Bifidobacterium, and brain phenotypes, among several others. We also identified genetic evidence consistent with modifiable relationships between circulating taurine and exposures, including bone mineral density, serum lactate, glycoproteins and creatinine. Collectively, this study systematically dissects the genetic basis of circulating taurine and highlights high-priority disease phenotypes requiring subsequent experimental validation for taurine-targeted nutritional and pharmacological strategies. (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: All the data analyzed in this study received ethical approval from the respective institutional review boards, informed consent from participants, and strict quality control. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. |
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| Grant Information: | U25A20154 National Natural Science Foundation of China; 2026ZD0558000 Noncommunicable Chronic Diseases-National Science and Technology Major Project; 2025ZNSFSC0641 Science and Technology Department of Sichuan Province |
| Contributed Indexing: | Keywords: Causal inference; Circulating taurine; Genetic correlation; Meta genome-wide association analysis; Phenome-wide Mendelian randomization study |
| Substance Nomenclature: | 1EQV5MLY3D (Taurine) |
| Entry Date(s): | Date Created: 20261005 Date Completed: 20261006 Latest Revision: 20261008 |
| Update Code: | 20261009 |
| DOI: | 10.1007/s10142-026-02067-9 |
| PMID: | 42834262 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1438-7948 |
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| DOI: | 10.1007/s10142-026-02067-9 |