Effects of Ciprofol- versus Remimazolam-Based Total Intravenous Anesthesia on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Controlled Trial.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Effects of Ciprofol- versus Remimazolam-Based Total Intravenous Anesthesia on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Controlled Trial.
Συγγραφείς:	Zeng J; Department of Anesthesiology and Pain Medicine, Jiangnan University Medical Center, Wuxi No. 2 People's Hospital, Wuxi, 214002, People's Republic of China., Ye Y; Department of Anesthesiology and Pain Medicine, Jiangnan University Medical Center, Wuxi No. 2 People's Hospital, Wuxi, 214002, People's Republic of China.; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, People's Republic of China., Li Z; Department of Anesthesiology and Pain Medicine, Jiangnan University Medical Center, Wuxi No. 2 People's Hospital, Wuxi, 214002, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China., Yang S; Department of Anesthesiology and Pain Medicine, Jiangnan University Medical Center, Wuxi No. 2 People's Hospital, Wuxi, 214002, People's Republic of China.; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, People's Republic of China., Jian J; Department of Anesthesiology, Affiliated Hospital of Jiangnan University, Wuxi, 214014, People's Republic of China., Huang D; Department of Anesthesiology and Pain Medicine, Jiangnan University Medical Center, Wuxi No. 2 People's Hospital, Wuxi, 214002, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China.
Πηγή:	Drug design, development and therapy [Drug Des Devel Ther] 2026 Sep 28; Vol. 20, pp. 624552. Date of Electronic Publication: 2026 Sep 28 (Print Publication: 2026).
Τύπος έκδοσης:	Comparative Study; Journal Article; Randomized Controlled Trial
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Imprint Name(s):	Original Publication: [Auckland, N.Z.] : Dove Press Limited
Ιατρικοί όροι (MeSH):	Anesthesia, Intravenous/adverse effects , Anesthesia, Intravenous/methods , Cholecystectomy, Laparoscopic/adverse effects , Postoperative Nausea and Vomiting/drug therapy , Postoperative Nausea and Vomiting/epidemiology , Postoperative Nausea and Vomiting/prevention & control, Antiemetics/administration & dosage ; Antiemetics/therapeutic use ; Cyclopropanes/administration & dosage ; Cyclopropanes/adverse effects ; Adult ; Female ; Humans ; Male ; Middle Aged
Περίληψη:	Background: Postoperative nausea and vomiting (PONV) remains common after laparoscopic cholecystectomy. Whether ciprofol-based anesthesia reduces PONV compared with remimazolam-based anesthesia remains unclear. Methods: In this single-center, randomized, assessor-blinded, parallel-group trial, adults undergoing laparoscopic cholecystectomy were assigned to receive ciprofol- or remimazolam-based total intravenous anesthesia. All participants received standardized antiemetic prophylaxis with dexamethasone and ondansetron, together with a standardized analgesic protocol. The primary outcome was the cumulative incidence of PONV within 24 h after surgery. Secondary outcomes included nausea, vomiting, rescue antiemetic use, postoperative pain, QoR-15 score, adverse events, and intraoperative hemodynamic variables. Results: A total of 146 patients were randomized, with 73 patients in each group. The incidence of PONV within 24 h was lower in the ciprofol group than in the remimazolam group [23/73 (31.5%) vs 43/73 (58.9%); RR 0.53, 95% CI 0.36-0.79; P = 0.001]. This association remained significant after adjustment for clinically relevant PONV risk factors(adjusted OR 0.289, 95% CI 0.135-0.623; P = 0.002). Ciprofol was also associated with lower incidences of nausea, vomiting, and rescue antiemetic use. Postoperative pain, QoR-15 score, overall adverse events, and vasopressor use were similar between groups. Conclusion: Under a standardized prophylactic antiemetic protocol, ciprofol-based total intravenous anesthesia was associated with a lower 24-h incidence of PONV than remimazolam-based anesthesia in adults undergoing laparoscopic cholecystectomy. No statistically significant between-group differences were observed in postoperative recovery measures, adverse events, or vasopressor use; however, the trial was not powered to establish equivalence for these secondary or safety outcomes. Further multicenter studies are needed to confirm the robustness and generalizability of this finding across different multimodal antiemetic strategies. (© 2026 Zeng et al.)
Competing Interests:	The authors declare no competing interests in this work.
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Contributed Indexing:	Keywords: ciprofol; laparoscopic cholecystectomy; postoperative nausea and vomiting; randomized controlled trial; remimazolam; total intravenous anesthesia
Substance Nomenclature:	0 ((2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol) 0 (Antiemetics) 0 (Cyclopropanes)
Entry Date(s):	Date Created: 20261003 Date Completed: 20261003 Latest Revision: 20261006
Update Code:	20261006
PubMed Central ID:	PMC13632637
DOI:	10.2147/DDDT.S624552
PMID:	42828344
Βάση Δεδομένων:	MEDLINE

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ISSN:	1177-8881
DOI:	10.2147/DDDT.S624552