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Biomedical Research Images Manipulated by Generative AI to Alter Scientific Outcomes: Diagnostic Study of Human and Automated Detection.

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Τίτλος: Biomedical Research Images Manipulated by Generative AI to Alter Scientific Outcomes: Diagnostic Study of Human and Automated Detection.
Συγγραφείς: Luo S; Department of Urology, China-Japan Friendship Hospital, Beijing, Beijing, China., Tang R; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China., Chen Z; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China., Wang J; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China., Liu M; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China., Wang J; Department of Urology, China-Japan Friendship Hospital, Beijing, Beijing, China., Ma L; Department of Intensive Care Medicine, The Second Hospital & The Second Clinical Medical College of Lanzhou University, No. 82 Cuiyingmen, Lanzhou, Gansu, 73003, China, 86 13893679654.
Πηγή: Journal of medical Internet research [J Med Internet Res] 2026 Oct 02; Vol. 28, pp. e100710. Date of Electronic Publication: 2026 Oct 02.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 100959882 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-8871 (Electronic) Linking ISSN: 14388871 NLM ISO Abbreviation: J Med Internet Res Subsets: MEDLINE
Imprint Name(s): Publication: <2011- > : Toronto : JMIR Publications
Original Publication: [Pittsburgh, PA? : s.n., 1999-
Ιατρικοί όροι (MeSH): Biomedical Research* , Artificial Intelligence* , Image Processing, Computer-Assisted*, Humans ; Generative Artificial Intelligence ; Animals
Περίληψη: Unlabelled: In a diagnostic study of 104 western blot and subcutaneous xenograft tumor images, a high-fidelity generative model produced forgeries that could alter the conclusions of a study; 24 PhD-level expert reviewers could not reliably distinguish the forgeries from authentic figures (mean accuracy 50.5%, SD 6.9%), while the best-performing commercial AI detector achieved only moderate discrimination (area under the curve 0.790, 95% CI 0.695-0.885), revealing critical vulnerabilities in current research-integrity safeguards.
(© Shuhang Luo, Runhua Tang, Ziyin Chen, Jianye Wang, Ming Liu, Jianfeng Wang, Li Ma. Originally published in the Journal of Medical Internet Research (https://www.jmir.org).)
References: Acta Neurochir (Wien). 2025 Aug 7;167(1):214. (PMID: 40773066)
PeerJ. 2025 Feb 20;13:e18988. (PMID: 39989748)
Health Sci Rep. 2025 Feb 19;8(2):e70200. (PMID: 39980823)
Front Artif Intell. 2025 Sep 02;8:1644098. (PMID: 40964145)
Medicine (Baltimore). 2024 Jul 5;103(27):e38811. (PMID: 38968491)
JAMA. 2023 Feb 28;329(8):637-639. (PMID: 36719674)
Saudi J Anaesth. 2023 Jul-Sep;17(3):401-406. (PMID: 37601525)
Nature. 2023 Jun;618(7964):222-223. (PMID: 37258739)
Sci Rep. 2025 Nov 23;15(1):44021. (PMID: 41276575)
Contributed Indexing: Keywords: AI-generated image detection; GPT Images 2.0; GenAI; biomedical image manipulation; conclusion-oriented falsification; generative artificial intelligence; research integrity
Entry Date(s): Date Created: 20261002 Date Completed: 20261002 Latest Revision: 20261005
Update Code: 20261005
PubMed Central ID: PMC13633064
DOI: 10.2196/100710
PMID: 42826371
Βάση Δεδομένων: MEDLINE
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  Data: Biomedical Research Images Manipulated by Generative AI to Alter Scientific Outcomes: Diagnostic Study of Human and Automated Detection.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Luo+S%22&quot;&gt;Luo S&lt;/searchLink&gt;; Department of Urology, China-Japan Friendship Hospital, Beijing, Beijing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Tang+R%22&quot;&gt;Tang R&lt;/searchLink&gt;; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Chen+Z%22&quot;&gt;Chen Z&lt;/searchLink&gt;; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+J%22&quot;&gt;Wang J&lt;/searchLink&gt;; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Liu+M%22&quot;&gt;Liu M&lt;/searchLink&gt;; Department of Urology, Beijing Hospital, Beijing, China, 8613911036970.; National Center for Gerontology, Beijing Hospital, Beijing, China.; National Clinical Research Center for Gerontology, Beijing Hospital, Beijing, China.; The Key Laboratory of Geriatrics of NHC, Beijing Hospital, Beijing, China.; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+J%22&quot;&gt;Wang J&lt;/searchLink&gt;; Department of Urology, China-Japan Friendship Hospital, Beijing, Beijing, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ma+L%22&quot;&gt;Ma L&lt;/searchLink&gt;; Department of Intensive Care Medicine, The Second Hospital &amp; The Second Clinical Medical College of Lanzhou University, No. 82 Cuiyingmen, Lanzhou, Gansu, 73003, China, 86 13893679654.
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  Data: Unlabelled: In a diagnostic study of 104 western blot and subcutaneous xenograft tumor images, a high-fidelity generative model produced forgeries that could alter the conclusions of a study; 24 PhD-level expert reviewers could not reliably distinguish the forgeries from authentic figures (mean accuracy 50.5%, SD 6.9%), while the best-performing commercial AI detector achieved only moderate discrimination (area under the curve 0.790, 95% CI 0.695-0.885), revealing critical vulnerabilities in current research-integrity safeguards.&lt;br /&gt; (&#169; Shuhang Luo, Runhua Tang, Ziyin Chen, Jianye Wang, Ming Liu, Jianfeng Wang, Li Ma. Originally published in the Journal of Medical Internet Research (https://www.jmir.org).)
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  Data: Acta Neurochir (Wien). 2025 Aug 7;167(1):214. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240773066%22&quot;&gt;40773066)&lt;/searchLink&gt;&lt;br /&gt;PeerJ. 2025 Feb 20;13:e18988. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239989748%22&quot;&gt;39989748)&lt;/searchLink&gt;&lt;br /&gt;Health Sci Rep. 2025 Feb 19;8(2):e70200. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2239980823%22&quot;&gt;39980823)&lt;/searchLink&gt;&lt;br /&gt;Front Artif Intell. 2025 Sep 02;8:1644098. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2240964145%22&quot;&gt;40964145)&lt;/searchLink&gt;&lt;br /&gt;Medicine (Baltimore). 2024 Jul 5;103(27):e38811. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2238968491%22&quot;&gt;38968491)&lt;/searchLink&gt;&lt;br /&gt;JAMA. 2023 Feb 28;329(8):637-639. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2236719674%22&quot;&gt;36719674)&lt;/searchLink&gt;&lt;br /&gt;Saudi J Anaesth. 2023 Jul-Sep;17(3):401-406. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237601525%22&quot;&gt;37601525)&lt;/searchLink&gt;&lt;br /&gt;Nature. 2023 Jun;618(7964):222-223. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2237258739%22&quot;&gt;37258739)&lt;/searchLink&gt;&lt;br /&gt;Sci Rep. 2025 Nov 23;15(1):44021. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2241276575%22&quot;&gt;41276575)&lt;/searchLink&gt;
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