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Functional Nausea Is Not Just Nausea: A Multi-Center, Cross-Sectional Study of Children and Young Adults.

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Τίτλος: Functional Nausea Is Not Just Nausea: A Multi-Center, Cross-Sectional Study of Children and Young Adults.
Συγγραφείς: El-Chammas K; Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Hagenstein L; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Chogle A; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children's Health of Orange County, Orange, California, USA., Santucci N; Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Graham K; Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Dorfman L; Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Kelly DR; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Atrium Health Levine Children's Hospital, Charlotte, North Carolina, USA., Dranove JE; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Atrium Health Levine Children's Hospital, Charlotte, North Carolina, USA., Rosen R; Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Children's Hospital Boston, Boston, Massachusetts, USA., Nurko S; Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Children's Hospital Boston, Boston, Massachusetts, USA., Croffie J; Division of Pediatric Gastroenterology, Hepatology & Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA., Balakrishnan K; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA., Chiou EH; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA., Simpson P; Division of Bioinformatics and Quantitative Child Health, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Karrento K; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Πηγή: Neurogastroenterology and motility [Neurogastroenterol Motil] 2026 Oct; Vol. 38 (10), pp. e70447.
Τύπος έκδοσης: Journal Article; Multicenter Study; Observational Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9432572 Publication Model: Print Cited Medium: Internet ISSN: 1365-2982 (Electronic) Linking ISSN: 13501925 NLM ISO Abbreviation: Neurogastroenterol Motil Subsets: MEDLINE
Imprint Name(s): Original Publication: Osney Mead, Oxford, UK : Blackwell Scientific Publications, c1994-
Ιατρικοί όροι (MeSH): Nausea*/epidemiology , Nausea*/diagnosis , Nausea*/physiopathology , Gastrointestinal Diseases*/epidemiology, Abdominal Pain/epidemiology ; Dyspepsia/epidemiology ; Anxiety/epidemiology ; Humans ; Female ; Cross-Sectional Studies ; Child ; Adolescent ; Male ; Young Adult
Περίληψη: Background: Chronic nausea is commonly associated with disorders of gut-brain interaction (DGBI). Pediatric functional nausea (FN) is defined as predominant nausea generally unrelated to meals. It is unclear if FN is a distinct entity or clustered with pain-associated DGBI. This multi-center study aimed to investigate the burden and comorbidities of FN and compare it to other DGBI.
Methods: Patients ages 8-21 years with DGBI were enrolled in a cross-sectional, multi-center observational registry across seven outpatient gastroenterology clinics and classified by Rome IV criteria. FN was compared to non-FN DGBI using validated symptom surveys: (1) Nausea Severity Scale (NSS), (2) Abdominal Pain Index (API), (3) PROMIS Global Health Scale (GHS), (4) PROMIS Pediatric Anxiety, (5) PROMIS Pediatric Depression, (6) Children's Somatization Inventory (CSI), and (7) Functional Disability Inventory (FDI).
Key Results: 292 subjects were analyzed. Fifty (17%) met FN criteria, of which 72% were female. Eighty-four and 32% of FN patients also met criteria for functional dyspepsia (FD) post-prandial distress subtype and irritable bowel syndrome (IBS), respectively. FN versus non-FN reported greater abdominal pain (p = 0.008), anxiety (p = 0.007) and depression (p = 0.002). FN versus IBS more commonly had long-term nausea and abdominal pain (p = 0.011, p = 0.014), postural dizziness (p = 0.034), migraines (p < 0.001), lower global health (p = 0.003), along with greater anxiety (p < 0.001) and depression (p < 0.001).
Conclusions and Inferences: Children who meet formal FN criteria do not have isolated nausea. FN overlaps highly with pain-associated DGBI, and nearly all FN patients report abdominal pain. FN is coupled with extra-intestinal symptoms, mental health comorbidities, and poor global health.
(© 2026 John Wiley & Sons Ltd.)
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Contributed Indexing: Keywords: diagnostic criteria; disorders of gut‐brain interaction; functional dyspepsia; functional nausea; nausea comorbidities
Local Abstract: [plain-language-summary] Functional nausea is a term used to diagnose patients suffering from predominant, chronic nausea that is typically unrelated to eating or vomiting. It is unclear if these patients suffer only from isolated nausea, and the broader symptom profile of these patients is overall poorly characterized. This study found that patients who fit the current diagnosis of functional nausea also meet diagnostic criteria for abdominal pain disorders such as irritable bowel syndrome. Patients with functional nausea also suffer from many other symptoms outside of the digestive tract along with mental health conditions and poor global health. Therefore, the results of this study suggest that functional nausea is not an isolated entity. Current diagnostic criteria may need to be revised based on these findings.
Entry Date(s): Date Created: 20261002 Date Completed: 20261002 Latest Revision: 20261005
Update Code: 20261006
DOI: 10.1111/nmo.70447
PMID: 42823909
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1365-2982
DOI:10.1111/nmo.70447