Academic Journal
Effect of Prematurity on Foveal Development During Infancy: Increased Foveal Inner and Outer Retina Layer Thicknesses in Extremely Premature Infants.
| Τίτλος: | Effect of Prematurity on Foveal Development During Infancy: Increased Foveal Inner and Outer Retina Layer Thicknesses in Extremely Premature Infants. |
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| Συγγραφείς: | Zhou XY; Department of Ophthalmology, University of Chicago, Chicago, Illinois, United States., Ying GS; Center for Preventive Ophthalmology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Tai V; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, United States., Mangalesh S; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, United States., Toth CA; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, United States., Chen X; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, United States. |
| Συλλογικό Έργο: | BabySTEPS Group |
| Πηγή: | Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2026 Oct 01; Vol. 67 (12), pp. 4. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo) Original Publication: St. Louis, Mosby. |
| Ιατρικοί όροι (MeSH): | Fovea Centralis*/growth & development , Fovea Centralis*/pathology , Retinopathy of Prematurity*/diagnosis , Retinopathy of Prematurity*/physiopathology , Infant, Extremely Premature*, Tomography, Optical Coherence/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Gestational Age ; Prospective Studies |
| Περίληψη: | Purpose: Foveation and inner retinal displacement are arrested in extremely premature infants through term equivalent age. We hypothesize that the effect of prematurity continues to impact the developing fovea in later stages of foveal development, well after term equivalent age. Methods: Infants enrolled in the STudy of Eye imaging in Preterm infantS (BabySTEPS1; NCT02887157) were imaged at four and nine months' corrected age. For infants with gradable imaging, foveal and parafoveal inner (IRL) and outer (ORL) retinal layer thicknesses were measured, with parafoveal/foveal thickness (P/F) ratios calculated. Univariate and multivariate regression analyses were performed to determine associations of birth and perinatal factors with foveation, and the effect of gestational age (GA) and history of macular edema on foveal thickness measurements. Results: In multivariate analysis of 99 eyes (56 infants) at four months and 70 eyes (44 infants, 34 infants overlapped with the four-months group) at nine months' corrected age, decreased P/F ratio was associated with lower GA (per week decrease) (four months: β (SE) = -0.109 (0.010, P < 0.0001; nine months: β (SE) = -0.063(0.011), P = 0.0005). Lower GA was associated with thicker foveal IRL (four months: β (SE) = 5.91 (0.76) µm, P < 0.0001; nine months: β (SE) = 3.95 (0.99) µm, P = 0.004) and ORL (four months: β (SE) = 4.86 (1.10) µm, P = 0.003; nine months: β (SE) = 4.46 (1.13) µm, P = 0.002). History of macular edema was associated with higher P/F ratios and thicker foveal ORL but not foveal IRL. Conclusions: Development of both inner and outer retina is altered in prematurity, and manifests from the time of preterm birth through infancy. During the first year of life, the most premature infants had shallower foveal pits and thicker IRL and ORL. Infants with a history of macular edema had thicker ORL. |
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| Grant Information: | P30 EY005722 United States EY NEI NIH HHS; R01 EY025009 United States EY NEI NIH HHS; R01 EY034134 United States EY NEI NIH HHS; R21 EY034138 United States EY NEI NIH HHS |
| Entry Date(s): | Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| PubMed Central ID: | PMC13648560 |
| DOI: | 10.1167/iovs.67.12.4 |
| PMID: | 42820799 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1552-5783 |
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| DOI: | 10.1167/iovs.67.12.4 |