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Quality over Quantity: Dietary Fatty Acid Composition Shapes Pancreatic Tumorigenesis.

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Τίτλος: Quality over Quantity: Dietary Fatty Acid Composition Shapes Pancreatic Tumorigenesis.
Συγγραφείς: Jeong YJ; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan., Lien EC; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan.; Van Andel Institute Graduate School, Grand Rapids, Michigan.
Πηγή: Cancer discovery [Cancer Discov] 2026 Oct 01; Vol. 16 (10), pp. 1961-1963.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Imprint Name(s): Original Publication: Philadelphia, PA : American Association for Cancer Research
Ιατρικοί όροι (MeSH): Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/etiology , Pancreatic Neoplasms*/pathology , Dietary Fats*/adverse effects , Carcinoma, Pancreatic Ductal*/etiology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/pathology , Fatty Acids*/metabolism , Carcinogenesis*, Animals ; Humans ; Mice ; Fatty Acids, Unsaturated
Περίληψη: Obesity and high dietary fat consumption are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC), and Ruiz and colleagues show that in addition to total fat consumption, distinct types of dietary fat contribute differently to tumor initiation in murine PDAC models. Diets rich in monounsaturated fatty acids enhance tumor progression, whereas dietary polyunsaturated fatty acids suppress tumorigenesis by increasing pancreatic cell susceptibility to lipid peroxidation and ferroptosis. See related article by Ruiz et al., p. 2108.
(©2026 American Association for Cancer Research.)
Substance Nomenclature: 0 (Dietary Fats)
0 (Fatty Acids)
0 (Fatty Acids, Unsaturated)
Entry Date(s): Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261001
Update Code: 20261001
DOI: 10.1158/2159-8290.CD-26-1528
PMID: 42817714
Βάση Δεδομένων: MEDLINE
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  Data: Quality over Quantity: Dietary Fatty Acid Composition Shapes Pancreatic Tumorigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Jeong+YJ%22">Jeong YJ</searchLink>; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan.<br /><searchLink fieldCode="AU" term="%22Lien+EC%22">Lien EC</searchLink>; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan.; Van Andel Institute Graduate School, Grand Rapids, Michigan.
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  Data: <searchLink fieldCode="JN" term="%22101561693%22">Cancer discovery</searchLink> [Cancer Discov] 2026 Oct 01; Vol. 16 (10), pp. 1961-1963.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Philadelphia, PA : American Association for Cancer Research
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  Data: <searchLink fieldCode="MM" term="%22Pancreatic+Neoplasms%22">Pancreatic Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Pancreatic+Neoplasms+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Pancreatic+Neoplasms%22">Pancreatic Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Pancreatic+Neoplasms+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Pancreatic+Neoplasms%22">Pancreatic Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Pancreatic+Neoplasms+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dietary+Fats%22">Dietary Fats*</searchLink>/<searchLink fieldCode="MM" term="%22Dietary+Fats+adverse+effects%22">adverse effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Carcinoma%2C+Pancreatic+Ductal%22">Carcinoma, Pancreatic Ductal*</searchLink>/<searchLink fieldCode="MM" term="%22Carcinoma%2C+Pancreatic+Ductal+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Carcinoma%2C+Pancreatic+Ductal%22">Carcinoma, Pancreatic Ductal*</searchLink>/<searchLink fieldCode="MM" term="%22Carcinoma%2C+Pancreatic+Ductal+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Carcinoma%2C+Pancreatic+Ductal%22">Carcinoma, Pancreatic Ductal*</searchLink>/<searchLink fieldCode="MM" term="%22Carcinoma%2C+Pancreatic+Ductal+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Fatty+Acids%22">Fatty Acids*</searchLink>/<searchLink fieldCode="MM" term="%22Fatty+Acids+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Carcinogenesis%22">Carcinogenesis*</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Fatty+Acids%2C+Unsaturated%22">Fatty Acids, Unsaturated</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Obesity and high dietary fat consumption are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC), and Ruiz and colleagues show that in addition to total fat consumption, distinct types of dietary fat contribute differently to tumor initiation in murine PDAC models. Diets rich in monounsaturated fatty acids enhance tumor progression, whereas dietary polyunsaturated fatty acids suppress tumorigenesis by increasing pancreatic cell susceptibility to lipid peroxidation and ferroptosis. See related article by Ruiz et al., p. 2108.<br /> (©2026 American Association for Cancer Research.)
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42817714
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        Value: 10.1158/2159-8290.CD-26-1528
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1961
    Subjects:
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Mice
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      – SubjectFull: Fatty Acids, Unsaturated
        Type: general
      – SubjectFull: Pancreatic Neoplasms metabolism
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      – SubjectFull: Pancreatic Neoplasms etiology
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      – SubjectFull: Pancreatic Neoplasms pathology
        Type: general
      – SubjectFull: Dietary Fats adverse effects
        Type: general
      – SubjectFull: Carcinoma, Pancreatic Ductal etiology
        Type: general
      – SubjectFull: Carcinoma, Pancreatic Ductal metabolism
        Type: general
      – SubjectFull: Carcinoma, Pancreatic Ductal pathology
        Type: general
      – SubjectFull: Fatty Acids metabolism
        Type: general
      – SubjectFull: Carcinogenesis
        Type: general
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      – TitleFull: Quality over Quantity: Dietary Fatty Acid Composition Shapes Pancreatic Tumorigenesis.
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              Text: 2026 Oct 01
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              Y: 2026
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