Academic Journal
Quality over Quantity: Dietary Fatty Acid Composition Shapes Pancreatic Tumorigenesis.
| Τίτλος: | Quality over Quantity: Dietary Fatty Acid Composition Shapes Pancreatic Tumorigenesis. |
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| Συγγραφείς: | Jeong YJ; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan., Lien EC; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan.; Van Andel Institute Graduate School, Grand Rapids, Michigan. |
| Πηγή: | Cancer discovery [Cancer Discov] 2026 Oct 01; Vol. 16 (10), pp. 1961-1963. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Philadelphia, PA : American Association for Cancer Research |
| Ιατρικοί όροι (MeSH): | Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/etiology , Pancreatic Neoplasms*/pathology , Dietary Fats*/adverse effects , Carcinoma, Pancreatic Ductal*/etiology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/pathology , Fatty Acids*/metabolism , Carcinogenesis*, Animals ; Humans ; Mice ; Fatty Acids, Unsaturated |
| Περίληψη: | Obesity and high dietary fat consumption are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC), and Ruiz and colleagues show that in addition to total fat consumption, distinct types of dietary fat contribute differently to tumor initiation in murine PDAC models. Diets rich in monounsaturated fatty acids enhance tumor progression, whereas dietary polyunsaturated fatty acids suppress tumorigenesis by increasing pancreatic cell susceptibility to lipid peroxidation and ferroptosis. See related article by Ruiz et al., p. 2108. (©2026 American Association for Cancer Research.) |
| Substance Nomenclature: | 0 (Dietary Fats) 0 (Fatty Acids) 0 (Fatty Acids, Unsaturated) |
| Entry Date(s): | Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261001 |
| Update Code: | 20261001 |
| DOI: | 10.1158/2159-8290.CD-26-1528 |
| PMID: | 42817714 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2159-8290 |
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| DOI: | 10.1158/2159-8290.CD-26-1528 |