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Human IgD+IgM- Memory B Cells and Their Possible Impact on Mucosal Homeostasis and Tolerance.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Human IgD+IgM- Memory B Cells and Their Possible Impact on Mucosal Homeostasis and Tolerance.
Συγγραφείς: Marcos-Fa X; Hospital de Mar Research Institute Barcelona (HMRIB), Barcelona, Spain., Guzmán M; Hospital de Mar Research Institute Barcelona (HMRIB), Barcelona, Spain., Corral-Vazquez C; Hospital de Mar Research Institute Barcelona (HMRIB), Barcelona, Spain., Cerutti A; Hospital de Mar Research Institute Barcelona (HMRIB), Barcelona, Spain.; Catalan Research Institute for Advanced Studies (ICREA), Barcelona, Spain.
Πηγή: Immunological reviews [Immunol Rev] 2026 Oct; Vol. 343 (1), pp. e70181.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print Cited Medium: Internet ISSN: 1600-065X (Electronic) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE
Imprint Name(s): Publication: <2002-> : Oxford : Blackwell
Original Publication: Copenhagen, Munksgaard.
Ιατρικοί όροι (MeSH): Immunoglobulin D*/immunology , Immunoglobulin D*/metabolism , Immunoglobulin M*/immunology , Immunoglobulin M*/metabolism , Memory B Cells*/immunology , Memory B Cells*/metabolism , B-Lymphocytes*/immunology , Mucous Membrane*/immunology , Immunologic Memory* , Immune Tolerance* , Immunity, Mucosal*, Homeostasis/immunology ; Germinal Center/immunology ; Plasma Cells/immunology ; Humans ; Animals ; Cell Differentiation ; Immunoglobulin Class Switching ; Signal Transduction
Περίληψη: This review discusses evidence indicating that the human nasopharyngeal mucosa includes a heterogeneous subset of memory B cells expressing IgD but not IgM. Such IgD+IgM- memory (IgD-ME) B cells differentiate from germinal center B cell precursors that have undergone class switching from IgM to IgD in tonsillar lymphoid follicles. This DNA recombination process is associated with a mutation-intensive program aimed at generating broadly reactive IgD antibodies that target a vast array of microbial and non-microbial antigens. We review data indicating that many IgD-ME B cells express atypical-like B cell properties, accumulate polyreactivity and some autoreactivity in a somatic hypermutation-dependent manner, and include precursors of IgD-secreting IgD+IgM- plasma cells (IgD-PCs). We further discuss the complex innate and adaptive signaling networks underlying the induction of IgD-ME B cells and their clonal differentiation into IgD-PCs. Furthermore, we consider the broad reactivity and functional effects of the IgD antibodies expressed by IgD-ME B cells and released by IgD-PCs. Moreover, we delve into the mechanisms whereby secreted IgD antibodies may contribute to mucosal tolerance and homeostasis. Lastly, we examine human disorders associated with abnormalities of the IgD response.
(© 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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Grant Information: PID2024-155263OB-I00 Ministerio de Ciencia e Innovación
Substance Nomenclature: 0 (Immunoglobulin D)
0 (Immunoglobulin M)
Entry Date(s): Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261001
Update Code: 20261001
DOI: 10.1111/imr.70181
PMID: 42817144
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1600-065X
DOI:10.1111/imr.70181