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Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span.
Συγγραφείς: Habel U; Institute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany. uhabel@ukaachen.de.; INM-10, Research Center Jülich, Jülich, Germany. uhabel@ukaachen.de., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany. reif@med.uni-frankfurt.de., Herpertz S; Department of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany. sabine.herpertz@uni-heidelberg.de., Konrad K; INM-10, Research Center Jülich, Jülich, Germany. kkonrad@ukaachen.de.; Institute of Medical Psychology and Medical Sociology, Uniklinik RWTH, Aachen, Aachen, Germany. kkonrad@ukaachen.de., Freitag C; Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany. c.freitag@em.uni-frankfurt.de., Banaschewski T; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. tobias.banaschewski@zi-mannheim.de., Frodl T; Department of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany. tfrodl@ukaachen.de., Barnes-Scheufler C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Berg L; Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Bertsch K; Department of Psychology I (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany., Chechko N; INM-10, Research Center Jülich, Jülich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany., Chiocchetti AG; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Ecker C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Ende G; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Fritsch A; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Gramegna C; Institute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany., Hanke M; INM-7, Research Center Jülich, Jülich, Germany.; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Holz N; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Hüpen P; Institute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany., Kuschel I; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Mathiak K; Department of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany., Maas A; Institute of Medical Psychology and Medical Sociology, Uniklinik RWTH, Aachen, Aachen, Germany., Meyer-Lindenberg A; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Neukel C; Department of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany., Paret C; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Plichta M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Reindl V; Institute of Medical Psychology and Medical Sociology, Uniklinik RWTH, Aachen, Aachen, Germany., Retz W; Institute for Forensic Psychology and Psychiatry, Saarland University, Homburg, Germany., Scharf J; Department of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany., Schmahl C; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Schirok H; Department of Psychiatry and Psychotherapy, University of Heidelberg, Heidelberg, Germany., Tost H; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Turner D; Leibniz Institute for Resilience Research (LIR), University Medical Center Mainz, Mainz, Germany., Tüscher O; Leibniz Institute for Resilience Research (LIR), University Medical Center Mainz, Mainz, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Medicine Halle (Saale) of the Martin Luther University Halle-Wittenberg (MLU) and German Center for Mental Health (DZPG), Halle (Saale), Germany., Wagels L; Institute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany.; INM-10, Research Center Jülich, Jülich, Germany., Weidler C; Institute for Translational Neuroscience and Clinical Psychology, Uniklinik RWTH, Aachen, Aachen, Germany., Zweerings J; Department of Psychiatry, Psychotherapy and Psychosomatics, Uniklinik RWTH Aachen, Aachen, Germany.
Πηγή: BMC psychiatry [BMC Psychiatry] 2026 Sep 30; Vol. 26 (1). Date of Electronic Publication: 2026 Sep 30.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BioMed Central, [2001-
Ιατρικοί όροι (MeSH): Aggression*/psychology , Aggression*/physiology , Mental Disorders*/psychology , Mental Disorders*/diagnosis , Mental Disorders*/physiopathology, Humans ; Female ; Adult ; Child ; Adolescent ; Male ; Young Adult ; Middle Aged ; Cross-Sectional Studies ; Longitudinal Studies ; Aged
Περίληψη: Background: Aggression in mental disorders (AMD) is a prevalent symptom, poses difficulties to the clinical setting and has far-reaching societal implications. The biological basis of different manifestations, developmental courses, and disease-specific mechanisms remains largely unknown. The lack of understanding of the complex mechanisms underlying AMD due to the heterogeneity of aggression and psychiatric disorders themselves, will be addressed by studying a longitudinal transdiagnostic cohort of patients suffering from mental disorders dimensionally quantified with respect to aggressive behavior.
Methods: Capitalizing on the Research Domain Criteria "negative valence system" (NVS) and "cognitive system" (CS), multilevel measurements of behavioral and biological systems provide a harmonized dataset at three study sites (Frankfurt, Mannheim/Heidelberg, Aachen; 900 adults, 200 children/youth) including forensic satellites (n = 150). A cross-sectional matched control group (300 adults, 100 youth) will also be included.
Discussion: The goal of the study is to provide a multilevel characterization of patients, assessing dimensional phenotypic measures across time points and diagnoses, to finally define aggressive biosignatures.
Trial Registration: The present study has been registered at https://drks.de/register/en/trial/DRKS00035731 (number of registration: DRKS00035731; date of registration: 20/02/2025).
(© 2026. The Author(s).)
Competing Interests: Declarations. Ethics approval: The review board of the Medical Faculty RWTH Aachen University Hospital approved the study (EK 24–270), in compliance with the latest version of the Code of Ethics of the World Medical Association (Declaration of Helsinki); the same applies to the review boards of Frankfurt Medical Faculty and Heidelberg Medical Faculty as well as Mannheim Central Institute of Mental Health, the participating recruitment sites. All participants will give oral and written informed consent and will receive financial compensation. For minors under 18, parents will give oral and written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
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Contributed Indexing: Keywords: Aggression; Cognitive system; Mental disorders; Negative valence system
Entry Date(s): Date Created: 20261001 Date Completed: 20261001 Latest Revision: 20261001
Update Code: 20261001
DOI: 10.1186/s12888-026-08359-5
PMID: 42816837
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1471-244X
DOI:10.1186/s12888-026-08359-5