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Unveiling Functional-Metabolic Synergy in the Healthy Brain: Multivariate Integration of Dynamic [18F]FDG-PET and Resting-State fMRI.

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Τίτλος: Unveiling Functional-Metabolic Synergy in the Healthy Brain: Multivariate Integration of Dynamic [18F]FDG-PET and Resting-State fMRI.
Συγγραφείς: Tarricone C; Department of Information Engineering, University of Padova, Padova, Italy.; Padova Neuroscience Center, University of Padova, Padova, Italy., Vallini G; Department of Information Engineering, University of Padova, Padova, Italy., Baron G; Department of Information Engineering, University of Padova, Padova, Italy.; Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.; Defitech Chair of Clinical Neuroengineering, INX, EPFL Valais, Sion, Switzerland., Facca M; Department of Information Engineering, University of Padova, Padova, Italy.; Padova Neuroscience Center, University of Padova, Padova, Italy., Silvestri E; Department of Information Engineering, University of Padova, Padova, Italy., Volpi T; Padova Neuroscience Center, University of Padova, Padova, Italy.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA., Vlassenko AG; Neuroimaging Laboratories at the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA., Goyal MS; Neuroimaging Laboratories at the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA., Bertoldo A; Department of Information Engineering, University of Padova, Padova, Italy.; Padova Neuroscience Center, University of Padova, Padova, Italy.
Πηγή: Human brain mapping [Hum Brain Mapp] 2026 Oct 01; Vol. 47 (14), pp. e70651.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
Imprint Name(s): Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
Ιατρικοί όροι (MeSH): Magnetic Resonance Imaging*/methods , Positron-Emission Tomography*/methods , Brain*/metabolism , Brain*/diagnostic imaging , Connectome*/methods , Nerve Net*/diagnostic imaging , Nerve Net*/metabolism , Nerve Net*/physiology , Glucose*/metabolism, Humans ; Fluorodeoxyglucose F18 ; Male ; Female ; Adult ; Radiopharmaceuticals ; Multimodal Imaging
Περίληψη: Despite accounting for only 2% of body weight, the human brain requires significant amounts of glucose, even at rest, underscoring the importance of functional-metabolic relationships. Previous studies revealed moderate associations between resting-state fMRI functional connectivity (FC) and local metabolism via [18F]FDG-PET, yet much remains to be understood, particularly regarding their coupling between functional and metabolic networks. To this end, we employed multivariate Partial Least Squares Correlation (PLSC) to investigate the functional-metabolic relationship at both nodal and network levels. From dynamic [18F]FDG-PET data we estimated parameters describing glucose metabolism-delivery rate (K1), phosphorylation rate (k3), and fractional uptake (Ki)-and generated within-individual metabolic connectivity (MC) networks. FC was derived from fMRI data filtered into two frequency bands and summarized as region-wise strength to capture nodal characteristics. Our findings revealed that glucose delivery is linked with FC strength, particularly when fMRI signal frequencies include greater hemodynamic contributions. Even stronger functional-metabolic coupling occurs at the network level in the low-frequency fMRI band, with higher MC between sensory/attention and transmodal networks supporting stronger FC within sensory/attention areas. By leveraging PLSC, this work deepens our understanding of the functional-metabolic synergy in the healthy brain, providing new insights into its organization.
(© 2026 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.)
Σχόλια: Update of: bioRxiv. 2025 May 27:2025.05.21.655345. doi: 10.1101/2025.05.21.655345.. (PMID: 40501582)
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Grant Information: project MNESYS; National Recovery and Resilience Plan; R01 AG057536 United States AG NIA NIH HHS; R01 AG053503 United States AG NIA NIH HHS; DN. 1553 11.10.2022 Ministero dell'Università e della Ricerca
Contributed Indexing: Keywords: BOLD frequency bands; dynamic [18F]FDG‐PET; functional‐metabolic integration; hemodynamics; partial least squares correlation
Substance Nomenclature: 0Z5B2CJX4D (Fluorodeoxyglucose F18)
IY9XDZ35W2 (Glucose)
0 (Radiopharmaceuticals)
Entry Date(s): Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20261006
Update Code: 20261006
PubMed Central ID: PMC13626976
DOI: 10.1002/hbm.70651
PMID: 42816435
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1097-0193
DOI:10.1002/hbm.70651