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Bioabsorbable Cold Plasma-Generated Nitric Oxide Gas and Plasma-Activated Nitric Oxide Water: Inactivation of Oral Planktonic and Biofilm-Forming Streptococcus mutans.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Bioabsorbable Cold Plasma-Generated Nitric Oxide Gas and Plasma-Activated Nitric Oxide Water: Inactivation of Oral Planktonic and Biofilm-Forming Streptococcus mutans.
Συγγραφείς: Ashokkumar S; Department of Bio-Nano Technology, Gachon University, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea., Bhatnagar A; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea., Acharya TR; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea.; GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Nottingham, UK., Shin YO; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea., Choi EH; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea., Lee YC; Department of Bio-Nano Technology, Gachon University, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea.
Πηγή: ChemPlusChem [Chempluschem] 2026 Oct; Vol. 91 (10), pp. e70257.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101580948 Publication Model: Print Cited Medium: Internet ISSN: 2192-6506 (Electronic) Linking ISSN: 21926506 NLM ISO Abbreviation: Chempluschem Subsets: MEDLINE
Imprint Name(s): Original Publication: Weinheim, Germany : Wiley-VCH, [c2012]-
Ιατρικοί όροι (MeSH): Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Nitric Oxide*/chemistry , Nitric Oxide*/pharmacology , Biofilms*/drug effects , Plasma Gases*/chemistry , Plasma Gases*/pharmacology , Water*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry, Staphylococcus aureus/drug effects ; Hydrogen Peroxide/chemistry
Περίληψη: Gas plasma exposure and plasma-activated water (PAW) containing long-lived reactive oxygen species (H2O2) and nitrogen species (NO2 ‒, NO3 ‒) generated by a multielectrode cylindrical dielectric barrier discharge plasma effectively inactivated oral bacteria Streptococcus mutans, opportunistic pathogen Staphylococcus aureus, and foodborne or intestinal Escherichia coli strains, which were used as comparator organisms. Gas plasma exposure to the water alters the water pH, H2O2, and NOx (Combined NO2 ‒ & NO3 ‒) concentrations. Gas Plasma (NOx and O3) achieved a 4-6 log reduction of bacteria within 16 min, while PAW induced a 5-6 log reduction within 3 days and reduced biofilm formation by 50 ± 0.21% ~ 40 ± 8.65%. These results show that bacteria, surface morphology, live/dead and RONS imaging, and flow cytometry consistently demonstrate that biocompatible plasma treatment significantly controls oral pathogens. Plasma gas and both distilled and tap-water PAW effectively inhibited S. mutans, with higher selectivity than that of other bacteria. This study highlights the potential of PAW as a novel, biocompatible strategy to mitigate the virulence of oral bacteria.
(© 2026 Wiley‐VCH GmbH.)
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Grant Information: RS-2021-NR060112 National Research Foundation (NRF) of Korea and the Korean Government; IRIS RS-2026-25536099 Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Korean Government (MOE)
Contributed Indexing: Keywords: Escherichia coli; Staphylococcus aureus; Streptococcus mutans; NOx & O3; gas plasma; oral bacteria; plasma‐activated water (PAW)
Substance Nomenclature: 31C4KY9ESH (Nitric Oxide)
0 (Plasma Gases)
059QF0KO0R (Water)
0 (Anti-Bacterial Agents)
BBX060AN9V (Hydrogen Peroxide)
Entry Date(s): Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20260930
Update Code: 20261001
DOI: 10.1002/cplu.70257
PMID: 42815024
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2192-6506
DOI:10.1002/cplu.70257