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Static and Dynamic Resting-State fMRI Connectivity Show Frequency-Resolved Associations With Intracranial EEG Connectivity.

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Τίτλος: Static and Dynamic Resting-State fMRI Connectivity Show Frequency-Resolved Associations With Intracranial EEG Connectivity.
Συγγραφείς: Rashnavadi T; Department of Radiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada., Sabaroedin K; Department of Radiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Department of Paediatrics, University of Calgary, Calgary, Canada., Wilson W; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada., Pittman DJ; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada., Federico P; Department of Radiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada., Levan P; Department of Radiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Seaman Family MR Research Centre, University of Calgary, Calgary, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
Πηγή: Human brain mapping [Hum Brain Mapp] 2026 Oct 01; Vol. 47 (14), pp. e70646.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
Imprint Name(s): Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
Ιατρικοί όροι (MeSH): Magnetic Resonance Imaging*/methods , Electrocorticography*/methods , Brain*/diagnostic imaging , Brain*/physiopathology , Brain*/physiology , Brain Waves*/physiology , Epilepsies, Partial*/physiopathology , Epilepsies, Partial*/diagnostic imaging , Connectome*/methods , Nerve Net*/diagnostic imaging , Nerve Net*/physiology , Nerve Net*/physiopathology, Neural Pathways/physiopathology ; Humans ; Female ; Adult ; Male ; Young Adult ; Rest ; Middle Aged
Περίληψη: Resting-state functional connectivity (FC) derived from functional MRI (fMRI) is widely used to characterize brain functional organization, yet its electrophysiological basis remains incompletely understood. Here, we investigated how electrophysiological connectivity relates to both static and dynamic fMRI connectivity using simultaneous intracranial EEG (icEEG)-fMRI recordings from 48 adults with focal epilepsy. Linear mixed-effects models were applied to sampled electrode-pair connections to examine frequency-resolved associations between band-limited icEEG connectivity and corresponding fMRI FC within non-epileptogenic brain regions. Time-averaged icEEG connectivity was robustly associated with spatial variation in static fMRI connectivity across sampled connections and frequency bands, with strongest effects in the beta and low-gamma ranges. At the window level, dynamic fMRI connectivity showed significant positive associations with window-specific icEEG FC deviations in the alpha, beta, and low-gamma bands. Exploratory spatial stratification suggested that cross-modal coupling varied across clinically sampled frontal, temporal, and insular region pairs, and the main findings remained robust after motion-control analyses. Together, these findings indicate that resting-state fMRI connectivity is associated with both average electrophysiological coupling across sampled connections and window-level fluctuations in electrophysiological connectivity, with the strongest primary band-wise evidence observed in the alpha, beta, and low-gamma ranges.
(© 2026 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.)
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Grant Information: RGPIN-2021-02797 Natural Sciences and Engineering Research Council of Canada (NSERC); PJT-183825 Canadian Institutes of Health Research (CIHR); Alberta Children's Hospital Research Institute; Hotchkiss Brain Institute, University of Calgary; HBI Inspires Postdoctoral Fellowship in Neuroscience; 2026 Canadian Neuroanalytics Scholars (CNS) Program
Contributed Indexing: Keywords: BOLD fluctuations; cross‐modal brain imaging; dynamic functional connectivity; intracranial EEG‐fMRI; neurovascular coupling; resting‐state functional connectivity; static functional connectivity
Entry Date(s): Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20261001
Update Code: 20261001
DOI: 10.1002/hbm.70646
PMID: 42813515
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1097-0193
DOI:10.1002/hbm.70646