Academic Journal
Paraventricular Hypothalamic GLP-1R Neurons Mediate Propofol-Induced Suppression of Food Intake.
| Τίτλος: | Paraventricular Hypothalamic GLP-1R Neurons Mediate Propofol-Induced Suppression of Food Intake. |
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| Συγγραφείς: | Liang J; Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China.; Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China., Yin M; Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China.; Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China., Su Y; Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China.; Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China., Zhang L; Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China.; Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China., Han Y; Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China.; Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699 Shanghai, China. |
| Πηγή: | Journal of integrative neuroscience [J Integr Neurosci] 2026 Sep 15; Vol. 25 (9), pp. 52398. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: IMR Press Country of Publication: Singapore NLM ID: 101156357 Publication Model: Print Cited Medium: Internet ISSN: 0219-6352 (Print) Linking ISSN: 02196352 NLM ISO Abbreviation: J Integr Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021-: Singapore : IMR Press Original Publication: London : Imperial College Press, c2002- |
| Ιατρικοί όροι (MeSH): | Propofol*/pharmacology , Propofol*/administration & dosage , Neurons*/drug effects , Neurons*/metabolism , Paraventricular Hypothalamic Nucleus*/drug effects , Paraventricular Hypothalamic Nucleus*/metabolism , Eating*/drug effects , Glucagon-Like Peptide-1 Receptor*/metabolism , Glucagon-Like Peptide-1 Receptor*/drug effects , Anesthetics, Intravenous*/pharmacology , Anesthetics, Intravenous*/administration & dosage, Feeding Behavior/drug effects ; Animals ; Male ; Mice ; Mice, Inbred C57BL |
| Περίληψη: | Background: Propofol is a widely used intravenous anesthetic, yet its impact on post-anesthetic feeding remains poorly characterized. The paraventricular nucleus of the hypothalamus (PVN) plays a key role in satiety regulation via glucagon-like peptide-1 receptor (GLP-1R) signaling. This study investigated whether PVNGLP-1R neurons mediate propofol-induced suppression in food intake. Methods: Food intake was measured in wild-type mice following different doses of propofol (25, 50, 100 mg/kg, i.p.) under different conditions (hunger, day and night). The neuronal activation during the period of feeding suppression by anesthesia was assessed via c-Fos immunohistochemistry. In Glp1r-Cre mice, PVNGLP-1R neurons were selectively activated or inhibited using optogenetics to determine their role in post-anesthetic feeding behavior. Fiber photometry with the calcium indicator GCaMP8m was used to record their activity in response to feeding onset during the recovery. Neural circuits were mapped using rabies virus (retrograde tracing) and synaptophysin-based virus (anterograde tracing). Results: An anesthetic dose of propofol (100 mg/kg, i.p.) suppressed food intake, regardless of circadian phase or metabolic state, whereas subanesthetic doses of propofol yielded inconsistent results depending on different scenarios. Propofol anesthesia increased c-Fos expression in PVNGLP-1R neurons. Fiber photometry revealed that propofol abolished the physiological decrease in PVNGLP-1R neuronal activity during food intake. The optogenetic activation of these neurons suppressed food intake, whereas inhibition promoted food intake in the post-anesthetic recovery period. Viral tracing revealed the upstream and downstream targets of PVNGLP-1R neurons and confirmed bidirectional connections between PVNGLP-1R neurons and the key appetite-related nuclei, including the lateral septum (LS), paraventricular thalamus (PVT), arcuate nucleus (ARC) and nucleus tractus solitarius (NTS). Conclusions: PVNGLP-1R neurons are essential mediators of the propofol-induced suppression of food intake. (Copyright: © 2026 The Author(s). Published by IMR Press.) |
| Grant Information: | 24ZR1463100 Natural Science Foundation of Shanghai |
| Contributed Indexing: | Keywords: feeding behavior; glucagon-like peptide-1 receptor; paraventricular hypothalamic nucleus; propofol |
| Substance Nomenclature: | YI7VU623SF (Propofol) 0 (Glucagon-Like Peptide-1 Receptor) 0 (Anesthetics, Intravenous) |
| Entry Date(s): | Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20260930 |
| Update Code: | 20260930 |
| DOI: | 10.31083/JIN52398 |
| PMID: | 42811901 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 0219-6352 |
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| DOI: | 10.31083/JIN52398 |