Academic Journal
Interaction of genetic and environmental risk factors in the aetiology of keratoconus.
| Τίτλος: | Interaction of genetic and environmental risk factors in the aetiology of keratoconus. |
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| Συγγραφείς: | Hadvina R; Center for Biotechnology and Genomic Medicine, Augusta University , Augusta, GA, USA.; Department of Ophthalmology, Mayo Clinic , Rochester, MN, USA., Liu Y; Center for Biotechnology and Genomic Medicine, Augusta University , Augusta, GA, USA.; Department of Ophthalmology, Mayo Clinic , Rochester, MN, USA. |
| Πηγή: | Open biology [Open Biol] 2026 Sep 30; Vol. 16 (9). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print Cited Medium: Internet ISSN: 2046-2441 (Electronic) Linking ISSN: 20462441 NLM ISO Abbreviation: Open Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Royal Society Pub., [2011]- |
| Ιατρικοί όροι (MeSH): | Keratoconus*/etiology , Keratoconus*/genetics , Keratoconus*/epidemiology , Gene-Environment Interaction* , Genetic Predisposition to Disease*, Ultraviolet Rays/adverse effects ; Environmental Exposure/adverse effects ; Humans ; Risk Factors ; Animals |
| Περίληψη: | Keratoconus (KC) is a multifactorial corneal ectasia disorder that is influenced by genetic and environmental risk factors. The manner and degree to which any risk factor contributes mechanistically to KC pathogenesis is not fully understood, despite epidemiological associations. Likewise, the relationship between genetic and environmental risk factors and how they may interact or compound upon one another to precipitate KC is largely unknown. In this review, we discuss existing research surrounding the genetic and environmental risk factors for KC, as well as the probable mechanisms driving individual risk factors such as ultraviolet radiation exposure and eye-rubbing. Additionally, we discuss the interplay between underlying genetic susceptibility to KC and contributory environmental factors. This review highlights advances in existing research in vivo and in vitro, potential underlying mechanisms and avenues for future inquiry to elucidate the multifactorial aetiology of KC. (© 2026 The Authors.) |
| Grant Information: | P30EY031631 NIH/NEI; R01EY032960 NIH/NEI; R01EY023242 NIH/NEI; R21EY033961 NIH/NEI; R21EY028671 NIH/NEI; F31EY036722 NIH/NEI |
| Contributed Indexing: | Keywords: gene–environment interaction; keratoconus; pathogenesis; risk factors |
| Entry Date(s): | Date Created: 20260930 Date Completed: 20260930 Latest Revision: 20260930 |
| Update Code: | 20260930 |
| DOI: | 10.1098/rsob.260068 |
| PMID: | 42811639 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2046-2441 |
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| DOI: | 10.1098/rsob.260068 |