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Diboron-Enabled Nickel-Catalyzed Intermolecular Reductive Coupling of Styrenes With Aldehydes.

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Τίτλος: Diboron-Enabled Nickel-Catalyzed Intermolecular Reductive Coupling of Styrenes With Aldehydes.
Συγγραφείς: Yin HT; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China., Wang YQ; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China., Xiao LJ; State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, China.
Πηγή: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2026 Sep 29, pp. e71743. Date of Electronic Publication: 2026 Sep 29.
Publication Model: Ahead of Print
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE
Imprint Name(s): Original Publication: Weinheim, Germany : Wiley-VCH
Περίληψη: The direct reductive coupling of alkenes with aldehydes offers an attractive alternative to conventional carbonyl addition using preformed organometallic reagents, yet intermolecular coupling of simple alkenes remains challenging. In this study, we report a diboron-enabled nickel-catalyzed reductive coupling of styrenes and related alkenes with aliphatic aldehydes to afford saturated alcohols with up to 93% yield and high linear regioselectivity. A diboron reagent/lithium methoxide (MeOLi) combination is crucial for productive coupling and enables broad functional-group tolerance. Deuterium-labeling and control experiments indicate that ethanol is the predominant hydrogen source and are consistent with a nickelacycle-based reductive pathway. This reaction establishes a complementary nickel-catalyzed manifold for direct alkene-aldehyde reductive coupling under mild conditions.
(© 2026 Wiley‐VCH GmbH.)
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Grant Information: 2022YFA1503200 National Key R&D Program of China; 22471134 National Natural Science Foundation of China; 63263152 Fundamental Research Funds for the Central Universities; 25HHWCSS00003 Haihe Laboratory of Sustainable Chemical Transformations; 25ZXZSSS00370 Tianjin Major Science and Technology Project for National Key Laboratories
Contributed Indexing: Keywords: aldehydes; alkenes; diboron reagents; nickel catalysis; reductive coupling
Entry Date(s): Date Created: 20260930 Latest Revision: 20260930
Update Code: 20260930
DOI: 10.1002/chem.71743
PMID: 42811386
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1521-3765
DOI:10.1002/chem.71743