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Novel genetic profile linked to cognitive decline in Hispanics/Latinos.

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Τίτλος: Novel genetic profile linked to cognitive decline in Hispanics/Latinos.
Συγγραφείς: Hrytsenko Y; Cardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Purushotham Y; Cardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Li Z; Cardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Isasi CR; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA., Tarraf W; Institute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, Michigan, USA., Ramos AR; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Daviglus ML; Department of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, USA., Parada H Jr; Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California, USA., Spitzer BW; Cardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Isshiki M; Departments of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA., Raj SM; Departments of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA., DeCarli C; Department of Neurology, University of California Davis, Sacramento, California, USA., González HM; Department of Neurosciences, University of California San Diego, La Jolla, California, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Sofer T; Cardiovascular division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Πηγή: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Oct; Vol. 22 (10), pp. e71855.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Imprint Name(s): Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
Ιατρικοί όροι (MeSH): Hispanic or Latino*/genetics , Cognitive Dysfunction*/genetics , Cognitive Dysfunction*/ethnology , Genetic Profile*, Apolipoproteins E/genetics ; Apolipoprotein E4/genetics ; Humans ; Female ; Male ; Aged ; Genetic Predisposition to Disease ; Alleles ; Whole Genome Sequencing
Περίληψη: Background: The APOE ε4 allele has weaker association with ADRD outcomes in Hispanic/Latino populations compared to non-Hispanic White and East Asian populations.
Methods: We used whole-genome sequencing data from 13,025 Hispanic/Latino adults to infer population groups (clusters) from short DNA sequences at the APOE gene region. We estimated the associations between these clusters and mild cognitive impairment (MCI) and age-adjusted significant cognitive decline assessed via the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) study (n = 5334). We compared these associations to those of the conventional APOE alleles.
Results: We identified three clusters of individuals. Relative to the largest Cluster 1, being in Cluster 3 had higher likelihood of having significant cognitive decline, with odds ratio (OR) = 1.47, 95% confidence interval (CI) [1.18, 1.84], p < 0.001. The association with having prevalent MCI at the SOL-INCA exam was not statistically significant, with OR = 1.33, 95% CI [0.97, 1.83], p = 0.08. Associations of the ε4 allele with these traits were not statistically significant.
Discussion: The new APOE profile has stronger risk association with age-adjusted significant cognitive decline in SOL-INCA Hispanics/Latinos compared to the ε4 allele.
(© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
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Grant Information: R01 AG075758 United States AG NIA NIH HHS; R01AG075758 United States AG NIA NIH HHS
Contributed Indexing: Keywords: APOE; APOE heterogeneity; Hispanic/Latino; age‐adjusted cognitive decline; apolipoprotein E; short genomic sequences; unsupervised clustering; whole‐genome sequencing
Substance Nomenclature: 0 (Apolipoproteins E)
0 (Apolipoprotein E4)
Entry Date(s): Date Created: 20260928 Date Completed: 20260928 Latest Revision: 20261001
Update Code: 20261001
PubMed Central ID: PMC13619723
DOI: 10.1002/alz.71855
PMID: 42805940
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1552-5279
DOI:10.1002/alz.71855