Academic Journal
Does the stria of Gennari integrity reflect acquired visual field defects?
| Τίτλος: | Does the stria of Gennari integrity reflect acquired visual field defects? |
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| Συγγραφείς: | Roelofzen C; Spinoza Centre for Neuroimaging, Amsterdam, Netherlands. c.roelofzen@spinozacentre.nl.; Computational Cognitive Neuroscience and Neuroimaging, Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, Netherlands. c.roelofzen@spinozacentre.nl.; Experimental and Applied Psychology, VU University Amsterdam, Amsterdam, Netherlands. c.roelofzen@spinozacentre.nl., Porro GL; Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands.; Ophthalmology, Amphia Hospital, Breda, Netherlands., van Genderen MM; Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands.; Bartiméus Diagnostic Centre for Complex Visual Disorders, Zeist, Netherlands., Bergsma DP; Cognitive Neuroscience, University Medical Centre St. Radboud, Nijmegen, Netherlands., Petridou N; Center for Image Sciences, University Medical Center, Utrecht, Netherlands., Dumoulin SO; Spinoza Centre for Neuroimaging, Amsterdam, Netherlands.; Computational Cognitive Neuroscience and Neuroimaging, Royal Netherlands Academy of Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.; Experimental and Applied Psychology, VU University Amsterdam, Amsterdam, Netherlands.; Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, Netherlands., Fracasso A; Department of General Psychology, University of Padua, Padua, Italy. alessio.fracasso@glasgow.ac.uk.; School of Psychology and Neuroscience, University of Glasgow, Glasgow, UK. alessio.fracasso@glasgow.ac.uk. |
| Πηγή: | Brain structure & function [Brain Struct Funct] 2026 Sep 26; Vol. 231 (8). Date of Electronic Publication: 2026 Sep 26. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101282001 Publication Model: Electronic Cited Medium: Internet ISSN: 1863-2661 (Electronic) Linking ISSN: 18632653 NLM ISO Abbreviation: Brain Struct Funct Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer-Verlag, c2007- |
| Ιατρικοί όροι (MeSH): | Visual Pathways*/pathology , Visual Pathways*/physiopathology , Visual Fields*/physiology , Primary Visual Cortex*/pathology , Primary Visual Cortex*/physiopathology , Hemianopsia*/pathology , Hemianopsia*/physiopathology , Hemianopsia*/etiology, Visual Cortex/pathology ; Optic Chiasm/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Female |
| Περίληψη: | Visual input reaches the primary visual cortex (V1) at the stria of Gennari, a band of highly myelinated fibers at the level of layer IV. Damage to the visual pathways can cause visual field defects (scotomas) that prevent visual input from reaching V1. Here, we evaluate whether the stria of Gennari degrades in the absence of visual input. Using 7 Tesla MRI, we investigate the integrity of the stria of Gennari in case of acquired homonymous visual field defects, in particular hemianopia: the loss of vision in half of the visual field. These visual field defects allow us to compare stria of Gennari integrity between the two hemispheres within the same participant, i.e., the hemisphere that is deprived of visual input (affected hemisphere) versus the hemisphere receiving visual information (unaffected hemisphere). Therefore, we focus on cases of acquired blindness following damage between the optic chiasm and V1. We quantify the stria of Gennari integrity both by measuring the T1-weighted intensity at the middle of cortical depth and using a modeling approach that captures T1-weighted intensity variations across cortical depth. Our results show that the stria of Gennari remains intact in both the affected and unaffected hemisphere, suggesting that the stria of Gennari integrity is not altered in the absence of visual input. (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
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| Grant Information: | 13339 NWO Vidi; 0.16.Vici.185.050 NWO Vici; 2016-35 UitZicht; BB/S006605/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; A-29315 Bial Foundation Grants Programme |
| Contributed Indexing: | Keywords: 7 T MRI; Acquired blindness; Myelin; Primary visual cortex; Stria of Gennari; Visual perception |
| Entry Date(s): | Date Created: 20260926 Date Completed: 20260926 Latest Revision: 20260926 |
| Update Code: | 20260927 |
| DOI: | 10.1007/s00429-026-03191-9 |
| PMID: | 42799918 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1863-2661 |
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| DOI: | 10.1007/s00429-026-03191-9 |