Academic Journal
Clinical significance of Chlamydia trachomatis and HPV coinfection across cervical lesion severity: a 10-year retrospective study in Southern China.
| Τίτλος: | Clinical significance of Chlamydia trachomatis and HPV coinfection across cervical lesion severity: a 10-year retrospective study in Southern China. |
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| Συγγραφείς: | Li H; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China.; Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China., Zhao H; Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China.; Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, China., Liang L; Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China.; Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, China., Chen M; Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China.; Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, China., Yang X; Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China.; Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, China. |
| Πηγή: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 Sep 11; Vol. 16, pp. 1832343. Date of Electronic Publication: 2026 Sep 11 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Media SA |
| Ιατρικοί όροι (MeSH): | Coinfection*/epidemiology , Coinfection*/microbiology , Coinfection*/virology , Chlamydia Infections*/epidemiology , Chlamydia Infections*/complications , Chlamydia trachomatis*/genetics , Chlamydia trachomatis*/isolation & purification , Papillomavirus Infections*/epidemiology , Papillomavirus Infections*/complications , Papillomavirus Infections*/pathology , Human Papillomavirus Viruses*/genetics , Human Papillomavirus Viruses*/isolation & purification, China/epidemiology ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/pathology ; Cervix Uteri/pathology ; Cervix Uteri/microbiology ; Humans ; Female ; Retrospective Studies ; Adult ; Prevalence ; Middle Aged ; DNA Methylation ; Young Adult ; Genotype |
| Περίληψη: | Background: Persistent high-risk HPV infection is the major cause of cervical carcinogenesis, but the clinical relevance of Chlamydia trachomatis (CT) coinfection remains uncertain. We examined the epidemiological patterns of CT-HPV coinfection and their associations with cervical lesion severity among women in Southern China. Methods: This retrospective study included 21,275 outpatients who underwent concurrent HPV genotyping, CT PCR testing, and cytological or histopathological evaluation between 2015 and 2024. Age-specific patterns and temporal trends were assessed. Age-adjusted logistic regression was used to examine associations of HPV and CT with cervical lesion categories. Six DNA methylation markers were analyzed in a subset of samples. Results: Overall prevalence was 25.7% for HPV, 8.7% for CT, and 3.8% for HPV-CT coinfection, with declining trends over time. CT infection and HPV-CT coinfection were more common in younger women. HPV positivity was significantly higher in CT-positive than CT-negative women (43.9% vs 23.9%, p < 0.001). CT infection and coinfection were more frequently observed in ASC-US/-H and LSIL, while CT showed weaker associations with advanced lesions and was not significantly associated with invasive cervical carcinoma. Among the six methylation markers, only PAX1 showed significant differences among the three groups, while HPV-CT coinfection was not associated with additional methylation alterations compared with HPV infection alone. Conclusions: CT infection and HPV-CT coinfection were concentrated in younger women and were more frequently associated with low-grade cervical abnormalities. CT positivity was also associated with a higher prevalence of HPV infection. (Copyright © 2026 Li, Zhao, Liang, Chen and Yang.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: Chlamydia trachomatis; DNA methylation; cervical lesions; coinfection; human papillomavirus |
| Entry Date(s): | Date Created: 20260926 Date Completed: 20260926 Latest Revision: 20260927 |
| Update Code: | 20260927 |
| PubMed Central ID: | PMC13612179 |
| DOI: | 10.3389/fcimb.2026.1832343 |
| PMID: | 42798386 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2235-2988 |
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| DOI: | 10.3389/fcimb.2026.1832343 |