Academic Journal
Multifocal Initiation of Spreading Depolarization by Generalized Tonic-Clonic Seizures.
| Τίτλος: | Multifocal Initiation of Spreading Depolarization by Generalized Tonic-Clonic Seizures. |
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| Συγγραφείς: | Smirnova M; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia., Karan A; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia., Medvedeva T; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia., Vinogradova L; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia. |
| Πηγή: | International journal of molecular sciences [Int J Mol Sci] 2026 Sep 21; Vol. 27 (18). Date of Electronic Publication: 2026 Sep 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2000- |
| Ιατρικοί όροι (MeSH): | Seizures*/physiopathology , Seizures*/chemically induced , Cortical Spreading Depression*/physiology , Hippocampus*/physiopathology, Cerebral Cortex/physiopathology ; Animals ; Male ; Rats ; Pentylenetetrazole ; Electroencephalography ; Disease Models, Animal ; Rats, Sprague-Dawley |
| Περίληψη: | Epileptic seizures are self-terminating events, yet the precise mechanisms underlying their cessation and the subsequent postictal suppression remain incompletely understood. Spreading depression (SD)-a traveling wave of intense depolarization and electrical silence-has emerged as a potential mechanism of focal seizure termination. Given that generalized tonic-clonic seizures involve widespread hyperexcitation of brain networks, we suggested that the seizures promote multifocal triggering of SD. Using a pentylenetetrazole seizure model and in vivo electrophysiology, we examined the occurrence of SD in different regions of the cortex and hippocampus in response to acute tonic-clonic seizures in freely behaving rats. We found that the seizures always induced SD within the first 20-40 s of ictal activity. SD was detected nearly simultaneously in all distant regions of the cortex and hippocampus. Most seizures were brief and culminated in SD. If the ictal discharge was long, cortical SD appeared mid-ictally. In the hippocampus, seizure-induced SD was partially blocked and spatially limited. Our findings support the idea that the awake brain rapidly responds to acute generalized seizures with multifocal initiation of SD in the cortex and hippocampus. We suggest that the seizure-induced SD contributes to seizure termination in the cortex but not in the hippocampus. |
| References: | Epilepsia. 2026 Mar;67(3):1078-1089. (PMID: 41204888) Brain. 2021 Oct 22;144(9):2863-2878. (PMID: 33768249) Neurol Res. 2020 Jan;42(1):76-82. (PMID: 31900075) Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):588-91. (PMID: 1470230) Cephalalgia. 2021 Mar;41(3):353-365. (PMID: 33164563) Front Cell Neurosci. 2021 Nov 26;15:761423. (PMID: 34899190) Neurobiol Dis. 2025 Jul;211:106937. (PMID: 40348201) Epilepsia. 2026 Jul;67(7):3815-3828. (PMID: 41984509) J Neurobiol. 1981 May;12(3):211-20. (PMID: 7276923) J Headache Pain. 2025 Nov 11;26(1):251. (PMID: 41219828) Sci Transl Med. 2025 Sep 17;17(816):eadv3260. (PMID: 40961224) Clin Neurophysiol. 2008 Sep;119(9):1973-84. (PMID: 18621582) Epilepsia. 2019 Dec;60(12):2386-2397. (PMID: 31755112) Brain Res. 2009 Aug 25;1286:201-7. (PMID: 19559681) Clin Neurophysiol. 2020 Dec;131(12):2861-2874. (PMID: 33152524) Biomedicines. 2026 Feb 28;14(3):. (PMID: 41898199) J Headache Pain. 2025 Feb 03;26(1):25. (PMID: 39901107) Nat Commun. 2021 Apr 13;12(1):2206. (PMID: 33850125) Epilepsia. 2008 Oct;49(10):1651-64. (PMID: 18503563) J Neurosci. 1997 Apr 1;17(7):2567-79. (PMID: 9065516) Brain Res. 2003 Jun 13;975(1-2):129-34. (PMID: 12763600) Brain. 2019 Feb 1;142(2):412-425. (PMID: 30649209) Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21116-21. (PMID: 23213262) Brain Res. 1993 Apr 9;608(1):107-14. (PMID: 8495335) Nat Commun. 2025 May 18;16(1):4619. (PMID: 40383825) Neurocrit Care. 2022 Jun;37(Suppl 1):31-48. (PMID: 35174446) Physiol Rev. 2001 Jul;81(3):1065-96. (PMID: 11427692) |
| Grant Information: | 22-15-00327-P Russian Science Foundation |
| Contributed Indexing: | Keywords: epilepsy; generalized seizures; hippocampus; postictal EEG depression; seizure termination; spreading depolarization |
| Substance Nomenclature: | WM5Z385K7T (Pentylenetetrazole) |
| Entry Date(s): | Date Created: 20260926 Date Completed: 20260926 Latest Revision: 20260929 |
| Update Code: | 20260929 |
| PubMed Central ID: | PMC13607438 |
| DOI: | 10.3390/ijms27188429 |
| PMID: | 42794854 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1422-0067 |
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| DOI: | 10.3390/ijms27188429 |