Academic Journal
Fospropofol vs Propofol for Early Postoperative Nausea and Vomiting Prophylaxis in High-Risk Patients Undergoing Gynecological Laparoscopic Surgery: A Randomized Controlled Trial.
| Τίτλος: | Fospropofol vs Propofol for Early Postoperative Nausea and Vomiting Prophylaxis in High-Risk Patients Undergoing Gynecological Laparoscopic Surgery: A Randomized Controlled Trial. |
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| Συγγραφείς: | Ma L; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Guo Y; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Wang W; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Lin C; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Yuan Y; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Wu H; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Liu Z; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China., Du W; Department of Anesthesiology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, People's Republic of China.; Shanghai Key Laboratory of Reproduction and Development, Shanghai, 200433, People's Republic of China. |
| Πηγή: | Drug design, development and therapy [Drug Des Devel Ther] 2026 Sep 19; Vol. 20, pp. 636353. Date of Electronic Publication: 2026 Sep 19 (Print Publication: 2026). |
| Τύπος έκδοσης: | Comparative Study; Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Auckland, N.Z.] : Dove Press Limited |
| Ιατρικοί όροι (MeSH): | Antiemetics*/administration & dosage , Gynecologic Surgical Procedures*/adverse effects , Laparoscopy*/adverse effects , Postoperative Nausea and Vomiting*/prevention & control , Postoperative Nausea and Vomiting*/drug therapy , Propofol*/administration & dosage , Propofol*/analogs & derivatives , Propofol*/analogs & derivatives, Adult ; Female ; Humans ; Middle Aged ; Prospective Studies |
| Περίληψη: | Background: Postoperative nausea and vomiting (PONV) is a common complication of gynecological laparoscopic surgeries. Although propofol has established antiemetic properties, the efficacy of its water-soluble prodrug, fospropofol, for PONV prophylaxis remains uncertain. The aim of this study was to compare the impact of fospropofol versus propofol on the incidence of PONV in high-risk patients undergoing gynecological laparoscopic surgery. Methods: In this prospective randomized controlled trial, 102 high-risk (Apfel score ≥3) female patients scheduled for elective gynecological laparoscopy were allocated to receive either fospropofol (FD group, n=51) or propofol (P group, n=51) for induction and maintenance, combined with sevoflurane inhalational anesthesia. The primary outcome was the incidence of PONV within the first 6 h postoperatively. Results: The incidence of PONV at 6 h was significantly lower in the FD group than in the P group (5.9% vs 19.6%; absolute risk reduction, 13.7%; P=0.038). Multivariable logistic regression confirmed that fospropofol was an independent protective factor (odds ratio 0.219; 95% CI 0.045-0.809; P=0.034). No significant between-group differences were observed in the PACU- or 24-h PONV rates. However, the FD group experienced a longer median time to extubation (14.0 vs 10.0 min, P=0.006) and a lower incidence of PACU pain (51.0% vs 72.5%, P=0.025). Conclusion: A reduction in early PONV within 6 hours was observed with fospropofol compared to propofol, suggesting a potential role for fospropofol in early PONV prevention. Clinical Trial Registration: ChiCTR2500114542. (© 2026 Ma et al.) |
| Competing Interests: | The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: antiemetic prophylaxis; fospropofol; gynecological laparoscopic surgery; postoperative nausea and vomiting; propofol; randomized controlled trial |
| Substance Nomenclature: | 0 (Antiemetics) LZ257RZP7K (fospropofol) YI7VU623SF (Propofol) |
| Entry Date(s): | Date Created: 20260925 Date Completed: 20260925 Latest Revision: 20260929 |
| Update Code: | 20260929 |
| PubMed Central ID: | PMC13601003 |
| DOI: | 10.2147/DDDT.S636353 |
| PMID: | 42787227 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1177-8881 |
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| DOI: | 10.2147/DDDT.S636353 |