Academic Journal
Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams.
| Τίτλος: | Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams. |
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| Συγγραφείς: | Lopez A; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA., Baikalov A; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Department of Radiation Oncology, School of Medicine and Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Institute of Radiation Medicine, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany., Liu K; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA., Esplen N; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Bartzsch S; Department of Radiation Oncology, School of Medicine and Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Institute of Radiation Medicine, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany., Schüler E; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA. |
| Πηγή: | Journal of applied clinical medical physics [J Appl Clin Med Phys] 2026 Oct; Vol. 27 (10), pp. e70819. |
| Τύπος έκδοσης: | Journal Article; Evaluation Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley on behalf of American Association of Physicists in Medicine Country of Publication: United States NLM ID: 101089176 Publication Model: Print Cited Medium: Internet ISSN: 1526-9914 (Electronic) Linking ISSN: 15269914 NLM ISO Abbreviation: J Appl Clin Med Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : Malden, MA : Wiley on behalf of American Association of Physicists in Medicine Original Publication: Reston, VA : American College of Medical Physics, c2000- |
| Ιατρικοί όροι (MeSH): | Particle Accelerators*/instrumentation , Radiometry*/instrumentation , Radiometry*/methods , Radiotherapy Planning, Computer-Assisted*/methods , Quality Assurance, Health Care*/standards , Electrons* , Phantoms, Imaging*, Humans ; Radiotherapy Dosage ; Equipment Design |
| Περίληψη: | Background: Beam diagnostic systems are essential for the development and quality assurance of ultra-high dose rate (UHDR) radiation sources to enable reliable delivery of FLASH radiotherapy (RT). Critically, suitable beam diagnostic systems for electron FLASH sources are lacking. Purpose: In this study, we evaluated a Faraday cup-style beam collector (BC), the BC-145-Al, on an UHDR electron linac for FLASH-RT applications. Methods: The BC performance was benchmarked against a reference alternating-current current transformer (ACCT) across a wide range of beam currents and pulse structures to test the BC's charge linearity and signal resolution capabilities. Two termination impedances were tested: 200 kΩ and 13 Ω. Results: The highly time-resolved signal of the BC was charge-proportional when terminated at 200 kΩ and current-proportional when terminated at 13 Ω, agreeing well with the time-resolved ACCT signal. The cumulative signals from the BC and ACCT showed excellent agreement, maintaining linearity with a deviation of less than ± 0.5% over 50 consecutive pulses (4-µs pulse width, 120-Hz pulse repetition frequency [PRF]). The BC/ACCT signal ratio remained stable within ± 0.5% as the PRF increased from 5 to 120 Hz at constant pulse width. Pulse width measurements from both detectors were also consistent within ± 0.5% across all nominal pulse width values (0.5-4 µs). When the charge per pulse was modulated by either increasing the pulse width or decreasing the source-to-surface distance (from 32.3 to 19.3 cm), the BC signal remained approximately linear with respect to the ACCT signal; however, the BC/ACCT ratio deviated by up to ± 6% across this range. Conclusions: The BC produced highly time-resolved absolute charge measurements of a pulsed UHDR electron beam across a large range of beam parameters. These results support its potential as a beam diagnostic system for both preclinical studies and clinical applications of electron FLASH radiotherapy. (© 2026 The Author(s). Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine.) |
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| Grant Information: | P30 CA016672 United States CA NCI NIH HHS; R01 CA266673 United States CA NCI NIH HHS; P30 CA016672 MD Anderson's Division of Radiation Oncology; by Cancer Center Support (Core); R01CA266673 United States NH NIH HHS |
| Contributed Indexing: | Keywords: FLASH radiotherapy; Faraday cup; beam diagnostics; ultra‐high dose rate |
| Entry Date(s): | Date Created: 20260925 Date Completed: 20260925 Latest Revision: 20260929 |
| Update Code: | 20260929 |
| PubMed Central ID: | PMC13612965 |
| DOI: | 10.1002/acm2.70819 |
| PMID: | 42786706 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1526-9914 |
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| DOI: | 10.1002/acm2.70819 |