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Regulation of Craving: Neural Correlates and the Role of Stress and Delay Discounting.

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Τίτλος: Regulation of Craving: Neural Correlates and the Role of Stress and Delay Discounting.
Συγγραφείς: Nickel-Grenke S; Dresden University of Technology, Faculty of Psychology, Dresden, Germany., Wüllhorst R; Dresden University of Technology, Faculty of Psychology, Dresden, Germany., Scherbaum S; Dresden University of Technology, Faculty of Psychology, Dresden, Germany., Schwarz K; Dresden University of Technology, Faculty of Psychology, Dresden, Germany., Endrass T; Dresden University of Technology, Faculty of Psychology, Dresden, Germany.
Πηγή: Addiction biology [Addict Biol] 2026 Oct; Vol. 31 (10), pp. e70190.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE
Imprint Name(s): Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996-
Ιατρικοί όροι (MeSH): Delay Discounting*/physiology , Craving*/physiology , Stress, Psychological*/physiopathology , Stress, Psychological*/psychology , Prefrontal Cortex*/physiopathology , Prefrontal Cortex*/diagnostic imaging, Ventral Striatum/physiopathology ; Ventral Striatum/diagnostic imaging ; Hydrocortisone/metabolism ; Dorsolateral Prefrontal Cortex/physiopathology ; Dorsolateral Prefrontal Cortex/diagnostic imaging ; Humans ; Male ; Magnetic Resonance Imaging ; Adult ; Young Adult ; Reward
Περίληψη: Regulation of craving (ROC) by focusing on long-term negative consequences of drug use has been shown to successfully reduce subjective craving. This process is supported by the dorsolateral prefrontal cortex (dlPFC), which exerts control over reward and value signals in the ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC). As stress impairs cognitive control and addiction is characterized by altered value computations manifesting in delay discounting, we examined how these factors interact with ROC and its neural correlates to better understand the use of ROC in high-risk situations. Sixty-eight male smokers underwent a delay discounting task and either a stress (socially evaluated cold pressor task) or a control condition. They subsequently completed a ROC task during fMRI while focusing on (1) long-term negative consequences (LATER) versus (2) short-term positive consequences (NOW). We found lower subjective craving ratings and attenuated neural responses in the VS (t = 4.33, p = 0.012) and vmPFC (t = 5.79, p < 0.001), as well as higher activation in the dlPFC (t = 4.09, p = 0.038) in the LATER compared to the NOW strategy. Although no neural or behavioural difference in ROC was observed between stress and control groups, both individual stress (cortisol) and delay discounting were positively related to vmPFC activity (NOW > LATER). We replicated previous results on ROC. Importantly, the association of vmPFC signals with stress response and delay discounting suggests that enhancing ROC success may involve reinforcing changes in self-referentiality of future thoughts to subjective value of drug use.
(© 2026 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
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Grant Information: EN 906/6-1 Deutsche Forschungsgemeinschaft
Contributed Indexing: Keywords: addiction; delay discounting; fMRI; regulation of craving; smoking; stress
Substance Nomenclature: WI4X0X7BPJ (Hydrocortisone)
Entry Date(s): Date Created: 20260924 Date Completed: 20260924 Latest Revision: 20260927
Update Code: 20260927
PubMed Central ID: PMC13612162
DOI: 10.1111/adb.70190
PMID: 42785753
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1369-1600
DOI:10.1111/adb.70190