Academic Journal
Drimane-Pyrone-Type Meroterpenoids and Co-Isolated Compounds from the Deep-Sea Fungus Penicillium rubens MABC05 and Their Anti-Ferroptotic and Cytotoxic Activities.
| Τίτλος: | Drimane-Pyrone-Type Meroterpenoids and Co-Isolated Compounds from the Deep-Sea Fungus Penicillium rubens MABC05 and Their Anti-Ferroptotic and Cytotoxic Activities. |
|---|---|
| Συγγραφείς: | Liu L; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China., Yang X; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China., Hu C; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China., Wang P; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China., Luo Z; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China., Lv Q; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China., Zhang Y; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China., Cheng Z; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China. |
| Πηγή: | Marine drugs [Mar Drugs] 2026 Sep 17; Vol. 24 (9). Date of Electronic Publication: 2026 Sep 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2003]- |
| Ιατρικοί όροι (MeSH): | Penicillium*/chemistry , Polycyclic Sesquiterpenes*/pharmacology , Polycyclic Sesquiterpenes*/chemistry , Pyrones*/pharmacology , Pyrones*/chemistry , Pyrones*/isolation & purification , Terpenes*/pharmacology , Terpenes*/chemistry , Terpenes*/isolation & purification, Kidney Tubules, Proximal/drug effects ; Humans ; Crystallography, X-Ray ; Molecular Structure |
| Περίληψη: | Ferroptosis is a critical driver of tubular necrosis, and its effective inhibition holds significant potential for mitigating renal injury. In this study, chemical investigation of the strain Penicillium rubens MABC05 yielded nine drimane-pyrone-type meroterpenoids (1-9), including six previously undescribed analogues, a previously undescribed tetrahydroxanthone-ergosterol hybrid (10), four steroids (11-14), and three xanthone derivatives (15-17). Their structures were elucidated via comprehensive spectroscopic analysis, supported by single-crystal X-ray diffraction (Mo Kα for 1 and 3, and Cu Kα for 6) and 13C NMR calculations (2 and 10). The absolute configurations of 1-5 and 10 were assigned by ECD calculation. Compounds 1-6 represent a rare group of meroterpenoids containing a fused drimane-type sesquiterpene and pyrone skeleton. Additionally, two storage-induced oxidative artifacts of 10 were also characterized. These compounds were evaluated for anti-ferroptotic and cytotoxic activities. Compound 15 exhibited inhibition against RSL3-induced ferroptosis in human renal proximal tubular epithelial cells with an EC |
| References: | Steroids. 2008 Jan;73(1):19-26. (PMID: 17900642) Chem Pharm Bull (Tokyo). 2006 Apr;54(4):550-3. (PMID: 16595963) Phytochemistry. 2016 Jun;126:4-10. (PMID: 27048854) J Nat Prod. 2014 Feb 28;77(2):406-10. (PMID: 24437979) Mar Drugs. 2025 Oct 16;23(10):. (PMID: 41149605) Bioorg Chem. 2024 Jul;148:107438. (PMID: 38761703) Bioorg Chem. 2025 Sep;164:108867. (PMID: 40819513) J Antibiot (Tokyo). 2005 Sep;58(9):559-65. (PMID: 16320760) J Nat Prod. 2024 Jun 28;87(6):1563-1573. (PMID: 38856635) Mar Drugs. 2025 Apr 30;23(5):. (PMID: 40422787) Chem Biodivers. 2023 Apr;20(4):e202300229. (PMID: 36866699) Mar Drugs. 2026 Jul 23;24(8):. (PMID: 42646455) Nat Prod Res. 2024 Jan-Feb;38(3):372-378. (PMID: 36111829) J Fungi (Basel). 2024 Jun 16;10(6):. (PMID: 38921410) Nat Prod Commun. 2013 Sep;8(9):1217-8. (PMID: 24273849) J Antibiot (Tokyo). 2023 Sep;76(9):563-566. (PMID: 37258804) J Nat Prod. 2023 Apr 28;86(4):830-841. (PMID: 36897077) ACS Chem Biol. 2025 Apr 18;20(4):823-829. (PMID: 40097246) J Org Chem. 2010 Dec 3;75(23):8224-33. (PMID: 21043439) |
| Grant Information: | 82460683 National Natural Science Foundation of China; KYQD(ZR)-23061 Hainan University |
| Contributed Indexing: | Keywords: Penicillium rubens; cytotoxicity; drimane-pyrone-type meroterpenoids; ferroptosis; tetrahydroxanthone-ergosterol hybrid |
| Substance Nomenclature: | 0 (drimane) 0 (Polycyclic Sesquiterpenes) 0 (Pyrones) 0 (Terpenes) |
| Entry Date(s): | Date Created: 20260924 Date Completed: 20260924 Latest Revision: 20260928 |
| Update Code: | 20260928 |
| PubMed Central ID: | PMC13608478 |
| DOI: | 10.3390/md24090326 |
| PMID: | 42783919 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1660-3397 |
|---|---|
| DOI: | 10.3390/md24090326 |