Patient-Controlled Real-Time Transcutaneous Electrical Acupoint Stimulation at Neiguan (PC6) for Chemotherapy-Induced Nausea and Vomiting in Breast Cancer: An Exploratory Single-Arm Two-Stage Trial.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Patient-Controlled Real-Time Transcutaneous Electrical Acupoint Stimulation at Neiguan (PC6) for Chemotherapy-Induced Nausea and Vomiting in Breast Cancer: An Exploratory Single-Arm Two-Stage Trial.
Συγγραφείς:	Liu H; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhou J; Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China., Du J; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou 310053, China., Shen Q; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China., Lu C; Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China., Zhang J; School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237, China., Zhang W; Department of Cancer, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310013, China., Ran R; Department of Cancer, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310013, China., Fang J; Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou 310053, China., Ye J; School of Information Science and Engineering, East China University of Science and Technology, Shanghai 200237, China., Gao H; Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China., Fang J; The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Πηγή:	Current oncology (Toronto, Ont.) [Curr Oncol] 2026 Aug 31; Vol. 33 (9). Date of Electronic Publication: 2026 Aug 31.
Τύπος έκδοσης:	Journal Article; Multicenter Study; Clinical Trial; Research Support, Non-U.S. Gov't
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE
Imprint Name(s):	Publication: 2021- : Basel, Switzerland : MDPI Original Publication: Toronto : Multimed, c1994-
Ιατρικοί όροι (MeSH):	Breast Neoplasms/drug therapy , Nausea/chemically induced , Nausea/therapy , Vomiting/chemically induced , Vomiting/therapy , Transcutaneous Electric Nerve Stimulation/methods , Antineoplastic Agents/adverse effects , Acupuncture Points, Humans ; Female ; Middle Aged ; Adult ; Aged
Περίληψη:	Chemotherapy-induced nausea and vomiting (CINV) remain difficult to control after discharge despite guideline-based antiemetics. This multicenter exploratory single-arm two-stage trial evaluated patient-controlled, real-time transcutaneous electrical acupoint stimulation (TEAS) at Neiguan (PC6) as an adjunct to standard antiemetic therapy in patients with breast cancer. Forty-eight patients who had experienced CINV and were scheduled at enrollment to receive the same chemotherapy and antiemetic regimens during two consecutive cycles were analyzed. Cycle 1 served as the observation period, and cycle 2 added on-demand wrist-worn TEAS initiated by patients at nausea or vomiting onset during 0-120 h after chemotherapy. Compared with the observation period, TEAS was associated with lower nausea frequency and visual analogue scale scores on days 1-5 and higher nausea response rates on days 1-4. Vomiting frequency and severity were lower on days 1-3, but between-period differences were not significant on days 4-5. SF-36 scores increased and SAS/SDS scores decreased on day 5. Two transient local numbness events occurred, with no serious TEAS-related adverse events. These findings suggest that patient-controlled TEAS is feasible and warrants confirmation in randomized sham-controlled trials.
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Grant Information:	GZY-ZJ-KJ-23072 Key project of Zhejiang Provincial Administration of Traditional Chinese Medicine; 2022YFC3500404 National Natural Science Foundation of China; 82174490 National Natural Science Foundation of China; 82374561 National Natural Science Foundation of China
Contributed Indexing:	Keywords: breast cancer; chemotherapy-induced nausea and vomiting; transcutaneous electrical acupoint stimulation
Substance Nomenclature:	0 (Antineoplastic Agents)
Entry Date(s):	Date Created: 20260924 Date Completed: 20260924 Latest Revision: 20261020
Update Code:	20261020
PubMed Central ID:	PMC13605070
DOI:	10.3390/curroncol33090520
PMID:	42782868
Βάση Δεδομένων:	MEDLINE

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ISSN:	1718-7729
DOI:	10.3390/curroncol33090520