Academic Journal
De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries.
| Τίτλος: | De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries. |
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| Συγγραφείς: | Yang L; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Behera A; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Meyers HJ; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Wang T; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA. |
| Πηγή: | Chembiochem : a European journal of chemical biology [Chembiochem] 2026 Sep 28; Vol. 27 (18), pp. e70532. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000- |
| Ιατρικοί όροι (MeSH): | Peptides, Cyclic*/genetics , Peptides, Cyclic*/chemistry , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/metabolism , Drug Discovery*/methods , Peptide Library*, Humans ; Animals |
| Περίληψη: | Cellular selection has emerged as a powerful approach for high throughput de novo discovery of bioactive cyclic peptides (CPs). This strategy coexpresses genetically encoded CP libraries with the target of interest in cells and uses customizable selection systems to link desired CP activities to a selectable phenotype to directly identify functional inhibitors. Cellular selections have yielded many CP inhibitors against a diverse range of therapeutic targets and have been continuously empowered by expansions in the CP diversity and selection repertoire. In this review, we summarize studies on cellular selection using genetically encoded CP libraries and discuss opportunities for future application of this technology. (© 2026 The Author(s). ChemBioChem published by Wiley‐VCH GmbH.) |
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| Grant Information: | R35 GM159851 United States GM NIGMS NIH HHS; R35 GM159851 United States NH NIH HHS |
| Contributed Indexing: | Keywords: cyclic peptide; genetic selections; peptides |
| Substance Nomenclature: | 0 (Peptides, Cyclic) 0 (Peptide Library) |
| Entry Date(s): | Date Created: 20260923 Date Completed: 20260923 Latest Revision: 20260925 |
| Update Code: | 20260925 |
| PubMed Central ID: | PMC13599706 |
| DOI: | 10.1002/cbic.70532 |
| PMID: | 42775926 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1439-7633 |
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| DOI: | 10.1002/cbic.70532 |