Academic Journal
Integrative multi-omics reveals that salvianolic acid a protects against septic liver injury by remodeling amino acid metabolism and redox homeostasis.
| Τίτλος: | Integrative multi-omics reveals that salvianolic acid a protects against septic liver injury by remodeling amino acid metabolism and redox homeostasis. |
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| Συγγραφείς: | Li P; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., He Y; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Fan Y; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Jia X; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Pei J; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Liu Y; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China., Gu X; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China. Electronic address: hkdguxy@163.com., Li L; Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address: lili0941@163.com. |
| Πηγή: | Protein and peptide letters [Protein Pept Lett] 2026 Sep; Vol. 34 (2), pp. 73-85. Date of Electronic Publication: 2026 Sep 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 9441434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-5305 (Electronic) Linking ISSN: 09298665 NLM ISO Abbreviation: Protein Pept Lett Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hilversum, The Netherlands : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1994- |
| Ιατρικοί όροι (MeSH): | Caffeic Acids*/pharmacology , Sepsis*/metabolism , Sepsis*/drug therapy , Sepsis*/complications , Lactates*/pharmacology , Liver*/metabolism , Liver*/pathology , Liver*/drug effects , Liver*/injuries , Amino Acids*/metabolism , Liver Diseases*/metabolism , Liver Diseases*/etiology , Liver Diseases*/prevention & control , Liver Diseases*/drug therapy , Liver Diseases*/pathology , Protective Agents*/pharmacology, Oxidation-Reduction/drug effects ; Homeostasis/drug effects ; Animals ; Mice ; Male ; Multiomics ; Mice, Inbred C57BL ; Proteomics |
| Περίληψη: | Background: Sepsis-induced liver injury (SILI) is a severe complication of sepsis associated with high morbidity and mortality. Salvianolic acid A (Sal A), a bioactive phenolic compound isolated from Salvia miltiorrhiza Bunge, exhibits hepatoprotective properties. However, its effects against SILI and underlying molecular mechanisms remain unclear. Methods: A cecal ligation and puncture (CLP)-induced murine sepsis model was established to evaluate the hepatoprotective effects of Sal A. Liver injury was assessed by serum biochemical assays and histopathological examination. Integrated transcriptomic, proteomic, and metabolomic analyses were performed to investigate the molecular mechanisms of Sal A-mediated hepatoprotection. Results: Sal A significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and alleviated hepatic histopathological injury in septic mice. Multi-omics analyses identified 236 differentially expressed genes (DEGs), 590 differentially expressed proteins (DEPs), and 370 differentially expressed metabolites (DEMs). Integrated analyses revealed that Sal A mainly regulated amino acid metabolism, oxidative stress, apoptosis, immune responses, and inflammatory signaling pathways, identifying key regulatory molecules and 37 shared metabolic pathways. Conclusions: Sal A protects against SILI through coordinated regulation of amino acid metabolism, redox homeostasis, apoptosis, immune responses, and inflammatory signaling pathways. Nevertheless, this study has several limitations, including the use of a CLP-induced mouse model, the preventive administration strategy rather than post-onset treatment, and the lack of direct mechanistic validation of key molecular targets. Further studies using clinically relevant therapeutic protocols and targeted experiments are required to confirm the translational potential of Sal A. (Copyright © 2026 The Authors. Publishing services by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interests None. |
| Contributed Indexing: | Keywords: Liver injury; Multi-omics; Proteomics analysis; Salvianolic acid A; Sepsis |
| Substance Nomenclature: | 0 (Caffeic Acids) 51622542XO (salvianolic acid A) 0 (Lactates) 0 (Amino Acids) 0 (Protective Agents) |
| Entry Date(s): | Date Created: 20260922 Date Completed: 20261012 Latest Revision: 20261012 |
| Update Code: | 20261013 |
| DOI: | 10.1016/j.ppl.2026.09.002 |
| PMID: | 42772374 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1875-5305 |
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| DOI: | 10.1016/j.ppl.2026.09.002 |