Academic Journal
Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.
| Τίτλος: | Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways. |
|---|---|
| Συγγραφείς: | Kenney KM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Burgener SS; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. |
| Πηγή: | Bioscience reports [Biosci Rep] 2026 Oct 21; Vol. 46 (10). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Portland Press on behalf of the Biochemical Society Original Publication: London : The Biochemical Society, c1981- |
| Ιατρικοί όροι (MeSH): | Glucocorticoids*/immunology , Glucocorticoids*/metabolism , Inflammation*/immunology , Inflammation*/metabolism , Inflammation*/pathology , Stress, Physiological*/immunology , Immunity, Innate*, Signal Transduction/immunology ; Humans ; Animals ; Innate Immunity Recognition |
| Περίληψη: | Despite our constant exposure to potential dangers, our ability to withstand infection and tissue damage relies on a network of coordinated cellular security systems. One of these security features is our innate immune system, which senses danger signals from invading pathogens as well as host-derived stress signals while remaining largely unresponsive to normal host molecules and the flora of the host microbiota. This intertwining network of cellular guardians expresses pattern recognition receptors to recognise specifically pathogen-associated molecular patterns and danger-associated molecular patterns and elicit an inflammatory response. Inflammation is an integral process to eliminate a pathogenic threat while simultaneously promoting tissue repair. However, a balance exists, and persistent or aberrant inflammation can instead drive tissue damage and disease. To douse inflammatory flames, the endocrine system releases endogenous glucocorticoids, which possess potent immunomodulatory actions. This review will explore the cross-talk between endogenous glucocorticoid signalling and innate immune signalling pathways. (© 2026 The Author(s).) |
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| Grant Information: | 21C133 Novartis Stiftung für Medizinisch-Biologische Forschung (Novartis Foundation for Medical-Biological Research) |
| Contributed Indexing: | Keywords: glucocorticoids; inflammation; innate immunity; stress |
| Substance Nomenclature: | 0 (Glucocorticoids) |
| Entry Date(s): | Date Created: 20260922 Date Completed: 20260922 Latest Revision: 20260925 |
| Update Code: | 20260925 |
| PubMed Central ID: | PMC13598316 |
| DOI: | 10.1042/BSR20250146 |
| PMID: | 42770217 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-4935 |
|---|---|
| DOI: | 10.1042/BSR20250146 |