Academic Journal
Impact of catheter angle on microsphere distribution in transarterial radioembolization: an in silico study based on ex vivo porcine liver data.
| Τίτλος: | Impact of catheter angle on microsphere distribution in transarterial radioembolization: an in silico study based on ex vivo porcine liver data. |
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| Συγγραφείς: | Snoeijink TJ; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. tess.snoeijink@radboudumc.nl.; Multi-Modality Medical Imaging Group, University of Twente, TechMed Center, Enschede, The Netherlands. tess.snoeijink@radboudumc.nl., Vlogman TG; Faculty of Engineering Technology, Department of Thermal and Fluid Engineering, University of Twente, Enschede, The Netherlands., van den Brekel A; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands., van der Hoek JL; Multi-Modality Medical Imaging Group, University of Twente, TechMed Center, Enschede, The Netherlands., Roosen J; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands., Groot Jebbink E; Multi-Modality Medical Imaging Group, University of Twente, TechMed Center, Enschede, The Netherlands., Jain K; Faculty of Engineering Technology, Department of Thermal and Fluid Engineering, University of Twente, Enschede, The Netherlands., Nijsen JFW; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. |
| Πηγή: | Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2026 Sep 21; Vol. 25 (5). Date of Electronic Publication: 2026 Sep 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 101135325 Publication Model: Electronic Cited Medium: Internet ISSN: 1617-7940 (Electronic) Linking ISSN: 16177940 NLM ISO Abbreviation: Biomech Model Mechanobiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin ; New York : Springer, c2002- |
| Ιατρικοί όροι (MeSH): | Radioembolization, Therapeutic*/methods , Liver*/diagnostic imaging , Liver*/blood supply , Microspheres* , Catheters* , Computer Simulation*, Hepatic Artery/diagnostic imaging ; Animals ; Swine ; Hydrodynamics |
| Περίληψη: | Computational fluid dynamics (CFD) simulations were conducted to explore the impact of catheter angle on microsphere distribution in transarterial radioembolization (TARE). The models were designed to closely replicate conditions from previously conducted ex vivo machine-perfused porcine liver experiments and therefore improve the perspective on microsphere distribution patterns. TARE with holmium-loaded microspheres was performed on an ex vivo machine-perfused porcine liver. Catheter position was imaged using angiography and ultrasound, the hepatic arterial vasculature using 3D cone beam CT, and lobe-specific microsphere distributions using holmium-sensitive T2*-weighted MRI scans. An in-house CFD model based on lattice Boltzmann and discrete element methods was developed. Simulations were parameterized with ex vivo porcine liver geometry and flow conditions as input. To further explore the role of catheter angles beyond experimental findings, four catheter angles (0°, 15°, 30°, and 45°), gradually directed toward the hepatic arterial wall, were evaluated using CFD. Ex vivo ultrasound imaging showed that the catheter was oriented at an angle of 25.2° toward the hepatic arterial wall. The simulations revealed that catheter angle strongly influences microsphere distribution, particularly in the branches closest to the injection position (lobe 3-5). The correlation between ex vivo and simulated microsphere distributions increased with catheter angle: from poor at 0° (r = 0.123), to moderate at 15° (r = 0.511), to very strong at 30° and 45° (r = 0.809 and r = 0.807, respectively). A catheter angle directed toward the hepatic arterial wall can affect microsphere distribution. In current clinical practice, the radial catheter position is not routinely visualized, complicating the reproducibility of catheter tip positioning between scout and therapeutic doses. Future research could focus on improved catheter tip visualization and the development of more stable catheter designs to enhance the reproducibility and efficacy of TARE. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interests: J.F.W. Nijsen is co-founder of Quirem Medical which has been acquired by Terumo Europe NV in July 2020. Nijsen has a scientific advisory role and is entitled to certain milestone payments from Terumo which are related to Quirem’s financial, operational and regulatory performance in the future. Furthermore, Nijsen is inventor on the patents related to radioactive microspheres that are assigned to University Medical Center Utrecht Holding BV, Quirem Medical or BASF Corp. The activities of Nijsen within Quirem Medical are approved and supported by the Board of Directors of the Radboudumc. The other authors declare that they have no conflict of interest. |
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| Grant Information: | 18427 Netherlands Organization for Scientific Research (NWO) |
| Contributed Indexing: | Keywords: Computational fluid dynamics; Distribution; Ex vivo; Microspheres; Radioembolization |
| Entry Date(s): | Date Created: 20260922 Date Completed: 20260922 Latest Revision: 20260924 |
| Update Code: | 20260924 |
| PubMed Central ID: | PMC13593647 |
| DOI: | 10.1007/s10237-026-02115-0 |
| PMID: | 42768236 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1617-7940 |
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| DOI: | 10.1007/s10237-026-02115-0 |