Implementing Congenital CMV Screening in a Large Hospital System.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Implementing Congenital CMV Screening in a Large Hospital System.
Συγγραφείς:	Tanzo J; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio., McBride L; Section for Pediatric Infectious Disease, Cleveland Clinic Children's Hospital, Cleveland, Ohio., Burke P; Department of Infection Prevention, Cleveland Clinic, Cleveland, Ohio., Jamis C; Department of Audiology, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio., Das A; Division of Neonatology, Cleveland Clinic Children's Hospital, Cleveland, Ohio., Aly H; Division of Neonatology, Cleveland Clinic Children's Hospital, Cleveland, Ohio., Anne S; Department of Otolaryngology, Head and Neck Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio., Schelzig C; Division of Pediatric Hospital Medicine, Cleveland Clinic Children's Hospital, Cleveland, Ohio., Jennings S; Division of Pediatric Hospital Medicine, Cleveland Clinic Children's Hospital, Cleveland, Ohio., Rhoads DD; Pathology and Laboratory Medicine Department, Cleveland Clinic, Cleveland, Ohio.; Microbial Sciences in Health Department, Cleveland Clinic, Cleveland, Ohio., Wang H; Pathology and Laboratory Medicine Department, Cleveland Clinic, Cleveland, Ohio., Esper F; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio.; Section for Pediatric Infectious Disease, Cleveland Clinic Children's Hospital, Cleveland, Ohio.
Πηγή:	Pediatrics [Pediatrics] 2026 Oct 01; Vol. 158 (4).
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE
Imprint Name(s):	Publication: Elk Grove Village Il : American Academy of Pediatrics Original Publication: Springfield, Ill., Thomas.
Ιατρικοί όροι (MeSH):	Neonatal Screening/methods , Neonatal Screening/organization & administration , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Infections/congenital , Cytomegalovirus Infections*/epidemiology, Ohio/epidemiology ; Humans ; Infant, Newborn ; Retrospective Studies ; Female ; Male
Περίληψη:	Background and Objectives: Congenital cytomegalovirus (cCMV) is the most common congenital infection and the leading nongenetic cause of sensorineural hearing loss. Despite expanding legislative screening requirements across the United States, there is no consensus guidance on the screening approach, resulting in wide variation in implementation. Our objective was to assess the outcomes and provide operational insights of initiating cCMV screening within a large hospital system. Methods: A multidisciplinary team representing key clinical and laboratory specialties developed a comprehensive cCMV screening and follow-up program. Infants born within the Cleveland Clinic Ohio enterprise were screened through a hybrid screening protocol (universal screening in neonatal intensive care units and targeted screening in newborn nurseries). Detection rates and implementation insights were compiled. Clinical outcomes were assessed through retrospective medical record review. Results: Among 50 438 live births, 7491 infants (14.9%) underwent cCMV screening from 2022 to 2025, increasing annual testing from approximately 150 to over 2000 infants. Thirty-four infants (0.45%) were confirmed to have cCMV, increasing case detection approximately 2.5-fold, with higher detection rates in targeted vs universal groups (0.74% vs 0.33%; P = .01). The most common clinical findings were abnormal neuroimaging (32.3%) and small for gestational age (26.5%). Although screening protocols were rapidly integrated into workflows, audiology follow-up was limited by logistical, socioeconomic, and educational barriers of families. Conclusions: Hybrid cCMV screening is feasible across a large health care system and increases detection. Multidisciplinary collaboration is essential to successful implementation. Improved access to audiology and other follow-up care is needed to maximize clinical impact. (Copyright © 2026 by the American Academy of Pediatrics.)
Entry Date(s):	Date Created: 20260920 Date Completed: 20260930 Latest Revision: 20260930
Update Code:	20261001
DOI:	10.1542/peds.2026-076776
PMID:	42764176
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1098-4275
DOI:	10.1542/peds.2026-076776