Academic Journal
Transcriptomic Landscape Reveals Immunity Related Trade-Offs in an Invertebrate-Fungal Host-Parasite System.
| Τίτλος: | Transcriptomic Landscape Reveals Immunity Related Trade-Offs in an Invertebrate-Fungal Host-Parasite System. |
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| Συγγραφείς: | Paraskevopoulou S; School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Biology, Lund University, Lund, Sweden., Gattis S; School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Ben-Ami F; School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. |
| Πηγή: | Molecular ecology [Mol Ecol] 2026 Sep; Vol. 35 (18), pp. e70543. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992- |
| Ιατρικοί όροι (MeSH): | Host-Parasite Interactions*/genetics , Host-Parasite Interactions*/immunology , Immunity, Innate*/genetics , Host-Pathogen Interactions*/genetics , Host-Pathogen Interactions*/immunology , Daphnia*/microbiology , Daphnia*/genetics , Daphnia*/immunology , Daphnia magna*/microbiology , Daphnia magna*/genetics , Daphnia magna*/immunology , Transcriptome* , Metschnikowia*, Reproduction/genetics ; Animals |
| Περίληψη: | Host-parasite interactions represent an evolutionary arms race, with parasites evolving strategies to exploit host resources, and hosts deploying mechanisms to resist or tolerate infection. Unlike vertebrates, which possess a sophisticated immune system, invertebrates rely entirely on innate immunity to combat pathogens. Yet, the molecular underpinnings and life-history consequences of immune activation remain little understood in non-insect invertebrates. Here, we combine life-history trait analysis with transcriptomics to investigate immune responses in an aquatic invertebrate exposed to a natural yeast parasite. By comparing infected, exposed-uninfected, and unexposed individuals, we identified candidate genes potentially involved in haemocyte recruitment and the reinforcement of the gut epithelium. These patterns highlight candidate mechanisms that may contribute to resistance following pathogen exposure. Exposed-uninfected individuals also showed delayed reproductive maturation, though lifetime reproductive output was ultimately maintained. Therefore, this suggests that successful exposure and immunity changes may be associated with a transient shift in reproductive allocation rather than a persistent reduction in reproductive output. In contrast, infected hosts exhibited stronger changes in metabolic and protein biosynthesis processes, consistent with a resource depletion hypothesis. These metabolic shifts align with reduced investment in reproduction, as infection appears to affect the number of offspring produced in the first brood. Our findings provide novel insights into the molecular and life-history responses associated with pathogen exposure and established infection and suggest candidate mechanisms through which host responses may shape life-history strategies in non-insect invertebrates, with broad implications for understanding host-parasite coevolution. (© 2026 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd.) |
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| Grant Information: | 938/16 Israel Science Foundation; The George S. Wise Faculty of Life Sciences |
| Contributed Indexing: | Keywords: Daphnia magna; Metschnikowia bicuspidata; RNA‐seq; host–parasite interactions; immune response |
| Entry Date(s): | Date Created: 20260918 Date Completed: 20260918 Latest Revision: 20260920 |
| Update Code: | 20260920 |
| PubMed Central ID: | PMC13587834 |
| DOI: | 10.1111/mec.70543 |
| PMID: | 42757851 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1365-294X |
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| DOI: | 10.1111/mec.70543 |