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Selective Impairment of Spatial Recognition Memory and Reduced Frontal Corticothalamic Spine Density Following Adolescent Alcohol Consumption.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Selective Impairment of Spatial Recognition Memory and Reduced Frontal Corticothalamic Spine Density Following Adolescent Alcohol Consumption.
Συγγραφείς: Qian G; Department of Anatomy and Cell Biology, LSU Health-New Orleans, New Orleans, Louisiana, USA., Jarrell H; Department of Anatomy and Cell Biology, LSU Health-New Orleans, New Orleans, Louisiana, USA., Maxwell F; Department of Anatomy and Cell Biology, LSU Health-New Orleans, New Orleans, Louisiana, USA., Mejia-Gomez H; Department of Anatomy and Cell Biology, LSU Health-New Orleans, New Orleans, Louisiana, USA., Salling MC; Department of Anatomy and Cell Biology, LSU Health-New Orleans, New Orleans, Louisiana, USA.; Alcohol & Drug Abuse Center of Excellence, LSU Health-New Orleans, New Orleans, Louisiana, USA.
Πηγή: Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2026 Sep; Vol. 50 (9), pp. e70415.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Periodicals Country of Publication: United States NLM ID: 9918609780906676 Publication Model: Print Cited Medium: Internet ISSN: 2993-7175 (Electronic) Linking ISSN: 29937175 NLM ISO Abbreviation: Alcohol Clin Exp Res (Hoboken) Subsets: MEDLINE
Imprint Name(s): Original Publication: Hoboken, NJ : Wiley Periodicals, [2023]-
Ιατρικοί όροι (MeSH): Prefrontal Cortex*/drug effects , Prefrontal Cortex*/pathology , Dendritic Spines*/drug effects , Dendritic Spines*/pathology , Spatial Memory*/drug effects , Spatial Memory*/physiology , Recognition, Psychology*/drug effects , Recognition, Psychology*/physiology , Alcohol Drinking*/adverse effects , Alcohol Drinking*/psychology , Alcohol Drinking*/pathology , Thalamus*/drug effects , Thalamus*/pathology, Animals ; Male ; Female ; Mice ; Mice, Inbred C57BL ; Ethanol
Περίληψη: Background: Heavy alcohol use is common during adolescence and is associated with an increased risk of alcohol use disorder and prevalence of residual cognitive deficits, especially in behaviors associated with the latently developing prefrontal cortex (PFC). A major need for advancing our understanding of this relationship is accessible preclinical behavioral batteries that can be used to disassociate the effects of adolescent alcohol on select PFC circuits.
Methods: The present study uses a retrograde viral approach to identify PFC projection neurons to the mediodorsal thalamus (MdT), followed by intermittent access to alcohol (IA EtOH) during adolescence on the 2-bottle choice procedure to model voluntary alcohol consumption. Following adolescent IA EtOH or water control, we evaluated performance on a battery of tasks to assess anxiety and cognition. Last, morphological analyses of spine density were performed for PFC-MdT neurons of adolescent IA EtOH and water control mice.
Results: Our results indicate that compared to water-only controls, male and female mice that voluntarily consumed alcohol during adolescence demonstrate performance deficits in the object-in-place recognition task, without affecting the novel object recognition task, Y-maze alternation, anxiety-like behavior, or locomotion, an outcome consistent with PFC and MdT dysfunction. Morphological assessment of PFC neurons from male and female mice following behavioral tasks found a reduction in spine density in basal and apical, but not oblique dendrites of PFC-MdT neurons.
Conclusions: Collectively, these results implicate PFC-to-MdT circuit integrity as a potential substrate for the effects of adolescent alcohol on spatial recognition memory.
(© 2026 Research Society on Alcohol.)
Σχόλια: Update of: bioRxiv. 2025 Dec 04:2025.12.02.691762. doi: 10.64898/2025.12.02.691762.. (PMID: 41573867)
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Grant Information: AA030619 United States AA NIAAA NIH HHS; AA024507 United States AA NIAAA NIH HHS
Substance Nomenclature: 3K9958V90M (Ethanol)
Entry Date(s): Date Created: 20260918 Date Completed: 20260918 Latest Revision: 20260922
Update Code: 20260922
DOI: 10.1111/acer.70415
PMID: 42754931
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2993-7175
DOI:10.1111/acer.70415