Academic Journal
When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease.
| Τίτλος: | When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease. |
|---|---|
| Συγγραφείς: | Zhao X; Cancer Center, The First Hospital of Jilin University, Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, China-Singapore Belt and Road Joint Laboratory on Liver Disease Research, The First Hospital of Jilin University, Changchun, China.; Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China.; International Center of Future Science, Jilin University, Changchun, China., Liu JH; Cancer Center, The First Hospital of Jilin University, Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, China-Singapore Belt and Road Joint Laboratory on Liver Disease Research, The First Hospital of Jilin University, Changchun, China.; Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China., Liu KY; Cancer Center, The First Hospital of Jilin University, Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, China-Singapore Belt and Road Joint Laboratory on Liver Disease Research, The First Hospital of Jilin University, Changchun, China.; Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China., Lin GC; Cancer Center, The First Hospital of Jilin University, Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, China-Singapore Belt and Road Joint Laboratory on Liver Disease Research, The First Hospital of Jilin University, Changchun, China.; Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China., Liu X; Cancer Center, The First Hospital of Jilin University, Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, China-Singapore Belt and Road Joint Laboratory on Liver Disease Research, The First Hospital of Jilin University, Changchun, China.; Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China., Wang Z; School of Medicine, Hebei University of Engineering, Handan, China., Zhou X; Cancer Center, The First Hospital of Jilin University, Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, China-Singapore Belt and Road Joint Laboratory on Liver Disease Research, The First Hospital of Jilin University, Changchun, China.; Cancer Research Institute of Jilin University, The First Hospital of Jilin University, Changchun, China.; International Center of Future Science, Jilin University, Changchun, China. |
| Πηγή: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2026 Sep 02; Vol. 14, pp. 1942974. Date of Electronic Publication: 2026 Sep 02 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| Περίληψη: | Lactate accumulation occurs in diverse physiological and pathological states, including hypoxia, ischemia, development, wound healing, immune activation, and cancer, where it functions as a key regulator of cellular energy metabolism, signal transduction, microenvironmental homeostasis, and immune responses. Protein lactylation was first described in 2019, revealing that lactate can serve as a substrate for post-translational protein modification. This review focuses on the bidirectional interplay between metabolic enzymes and lactylation. On one hand, metabolic enzymes control lactate production and thereby shape the lactylation landscape. On the other hand, lactylation exerts feedback regulation through two mechanisms: directly, lactylation of metabolic enzymes per se alters enzyme properties, including activity, stability, and interactions; indirectly, histone lactylation epigenetically modulates the expression of metabolic enzymes, and the lactylation of other proteins alters the expression or activity of metabolic enzymes. Through this integrated framework, we aim to elucidate how lactylation influences the functional traits of metabolic enzymes and how lactylation of metabolic enzymes, in turn, affects disease onset and progression. Finally, we explore whether targeting lactylation of metabolic enzymes could emerge as a promising therapeutic avenue. (Copyright © 2026 Zhao, Liu, Liu, Lin, Liu, Wang and Zhou.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor YH declared a shared affiliation with the authors XZ, JL, KL, GL, XL, and XZ at the time of review. |
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| Contributed Indexing: | Keywords: interplay; lactate; lactylation; metabolic enzymes; metabolism |
| Entry Date(s): | Date Created: 20260917 Date Completed: 20260917 Latest Revision: 20260918 |
| Update Code: | 20260918 |
| PubMed Central ID: | PMC13578978 |
| DOI: | 10.3389/fcell.2026.1942974 |
| PMID: | 42750984 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2296-634X |
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| DOI: | 10.3389/fcell.2026.1942974 |