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Breaking the Limitations of 'Milk': Research Progress on New Derivatives of Propofol.

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Τίτλος: Breaking the Limitations of 'Milk': Research Progress on New Derivatives of Propofol.
Συγγραφείς: Huang L; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Xia Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China., Shi J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China., Chen Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China., Hao C; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
Πηγή: Molecules (Basel, Switzerland) [Molecules] 2026 Aug 31; Vol. 31 (17). Date of Electronic Publication: 2026 Aug 31.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI, c1995-
Ιατρικοί όροι (MeSH): Propofol*/chemistry , Propofol*/analogs & derivatives , Propofol*/adverse effects , Propofol*/pharmacology , Propofol*/therapeutic use , Anesthetics, Intravenous*/chemistry , Anesthetics, Intravenous*/therapeutic use , Anesthetics, Intravenous*/adverse effects , Anesthetics, Intravenous*/pharmacology, Humans ; Animals ; Solubility
Περίληψη: Over the past several decades, intravenously administered anesthetics such as propofol have gained widespread recognition for their use in inducing and maintaining general anesthesia. As a fast-acting, short-acting anesthetic, propofol exhibits rapid onset, brief duration, excellent induction efficacy, minimal accumulation, and promotes clear-headedness and swift recovery post-anesthesia. However, its poor water solubility necessitates formulation as an emulsion, which may cause injection site pain during administration and potentially lead to allergic reactions and lipid metabolism disorders. In light of this, pharmacologists aim to optimize propofol through structural modification, seeking to develop a systemic intravenous anesthetic that mitigates or improves these side effects.
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Contributed Indexing: Keywords: gamma-aminobutyric acid receptor; general anesthetic; intravenous anesthetic; pain; propofol
Substance Nomenclature: YI7VU623SF (Propofol)
0 (Anesthetics, Intravenous)
Entry Date(s): Date Created: 20260915 Date Completed: 20260915 Latest Revision: 20260916
Update Code: 20260916
PubMed Central ID: PMC13567372
DOI: 10.3390/molecules31173066
PMID: 42738725
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1420-3049
DOI:10.3390/molecules31173066