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Effects of Repeated Partial Daily Social Isolation and Treadmill Exercise on Spatial Memory and Hippocampal Long-Term Potentiation in Male Rats.

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Τίτλος: Effects of Repeated Partial Daily Social Isolation and Treadmill Exercise on Spatial Memory and Hippocampal Long-Term Potentiation in Male Rats.
Συγγραφείς: Ezgin N; Institute of Natural and Applied Sciences, Department of Biotechnology, Cukurova University, Adana, Turkey.; Institute of Medical Physiology 'Richard Burian,' Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Yousef M; Faculty of Medicine, Department of Physiology, Erciyes University, Kayseri, Turkey., Cevik ÖS; Faculty of Medicine, Department of Physiology, Mersin University, Mersin, Turkey., Suer C; Faculty of Medicine, Department of Physiology, Erciyes University, Kayseri, Turkey., Sahin L; Faculty of Medicine, Department of Physiology, Mersin University, Mersin, Turkey.
Πηγή: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2026 Oct; Vol. 86 (6), pp. e70177.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 8401784 Publication Model: Print Cited Medium: Internet ISSN: 1873-474X (Electronic) Linking ISSN: 07365748 NLM ISO Abbreviation: Int J Dev Neurosci Subsets: MEDLINE
Imprint Name(s): Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Inc.
Original Publication: Oxford : New York : Pergamon Press, c1983-
Ιατρικοί όροι (MeSH): Social Isolation*/psychology , Long-Term Potentiation*/physiology , Hippocampus*/physiology , Spatial Memory*/physiology , Physical Conditioning, Animal*/physiology, Maze Learning/physiology ; Animals ; Male ; Rats, Wistar ; Rats ; Body Weight
Περίληψη: Objectives: Stress-related experiences during early developmental periods may influence behavioural outcomes and hippocampal function. Social isolation is widely used as an experimental stress model, while physical exercise is considered a potential behavioural modulator. This study investigated the effects of treadmill exercise on behavioural performance and hippocampal synaptic plasticity following repeated partial daily social isolation in male rats.
Methods: Male Wistar rats (postnatal day 28) were assigned to control or repeated partial daily social isolation conditions (6 h/day for 6 weeks). Treadmill exercise was applied once daily for 4 weeks, starting after 2 weeks of isolation. Food and water intake and body weight were recorded weekly. Spatial learning and memory were assessed using the Morris Water Maze test, and hippocampal synaptic plasticity was evaluated via long-term potentiation (LTP) recordings from the dentate gyrus.
Results: Social isolation and treadmill exercise significantly increased food and water consumption without affecting body weight. Social isolation did not significantly affect spatial learning, memory performance or dentate gyrus LTP. No significant differences were observed in Morris Water Maze performance or LTP measures among groups.
Discussion: These findings indicate that this moderate, intermittent isolation paradigm did not produce detectable alterations in hippocampal-dependent spatial memory performance or dentate gyrus synaptic plasticity under the present experimental conditions.
(© 2026 International Society for Developmental Neuroscience.)
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Grant Information: 2017-1-TP2-2217 Mersin University Research Fund
Contributed Indexing: Keywords: exercise; long‐term potentiation; neuroplasticity; social isolation; spatial memory
Entry Date(s): Date Created: 20260914 Date Completed: 20260914 Latest Revision: 20260923
Update Code: 20260923
PubMed Central ID: PMC13574528
DOI: 10.1002/jdn.70177
PMID: 42735944
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-474X
DOI:10.1002/jdn.70177