Academic Journal
Free-Breathing Arterial Spin Labeling MRI of the Kidney Using Flow-Sensitive-Alternating Inversion Recovery With Golden-Angle Radial Sampling.
| Τίτλος: | Free-Breathing Arterial Spin Labeling MRI of the Kidney Using Flow-Sensitive-Alternating Inversion Recovery With Golden-Angle Radial Sampling. |
|---|---|
| Συγγραφείς: | Zhang Y; School of Biomedical Engineering, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China., Zhang W; School of Biomedical Engineering, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China., Sun S; School of Biomedical Engineering, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China., Li C; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China., Wang J; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China., Wu P; Philips Healthcare, Shanghai, China., Xie D; Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; National Clinical Research Center for Kidney Disease, Guangzhou, China.; State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangzhou, China.; Guangdong Provincial Institute of Nephrology, Guangzhou, China., Niendorf T; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbruck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Tao Q; School of Biomedical Engineering, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China., Chen Z; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China., Feng Y; School of Biomedical Engineering, Southern Medical University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China.; State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangzhou, China.; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou, China.; Key Laboratory of Mental Health of the Ministry of Education, Guangzhou, China.; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Southern Medical University, Guangzhou, China. |
| Πηγή: | NMR in biomedicine [NMR Biomed] 2026 Oct; Vol. 39 (10), pp. e70397. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: England NLM ID: 8915233 Publication Model: Print Cited Medium: Internet ISSN: 1099-1492 (Electronic) Linking ISSN: 09523480 NLM ISO Abbreviation: NMR Biomed Subsets: MEDLINE |
| Imprint Name(s): | Publication: Chichester : Wiley Original Publication: London : Heyden & Son, 1988- |
| Ιατρικοί όροι (MeSH): | Kidney*/diagnostic imaging , Kidney*/blood supply , Spin Labels* , Respiration* , Magnetic Resonance Imaging* , Renal Circulation*, Humans ; Male ; Adult ; Female ; Reproducibility of Results ; Perfusion Magnetic Resonance Imaging ; Middle Aged ; Young Adult |
| Περίληψη: | Renal function critically depends on adequate perfusion. Arterial spin labeling (ASL) MRI enables noninvasive perfusion quantification but is highly susceptible to respiratory motion artifacts in renal applications. In this work, we developed and validated a free-breathing renal ASL technique using flow-sensitive alternating inversion recovery with golden-angle radial sampling and motion-corrected reconstruction. Eleven healthy volunteers (25 ± 2.1 years, six male) and nine Stage 2 chronic kidney disease (CKD) patients (42 ± 17 years) were enrolled. Healthy subjects underwent repeat scans after a 1-week interval for test-retest assessment. A breath-hold turbo spin-echo ASL sequence served as the reference. Renal blood flow (RBF) in the cortex and medulla was quantified using the Buxton model. The proposed free-breathing approach showed strong agreement with the breath-hold reference (coefficient of variation [CoV] = 8.8%) and excellent scan-rescan repeatability (CoV = 7.7%). Mean bias between free-breathing and breath-hold RBF measurements was 13 ± 21 mL/100 g/min (p < 0.001). In healthy volunteers, cortical RBF was 249 ± 19 mL/100 g/min and medullary RBF 138 ± 20 mL/100 g/min; in CKD patients, these values were significantly reduced to 144 ± 34 and 75 ± 15 mL/100 g/min, respectively (p < 0.001). This free-breathing ASL technique provides a reliable and repeatable foundation for RBF assessment that does not require breath-holding, facilitating broader clinical applicability particularly in patients with limited respiratory capacity, and offers potential for investigating renal pathophysiology. (© 2026 John Wiley & Sons Ltd.) |
| References: | Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii4-ii14. (PMID: 30137584) Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii15-ii21. (PMID: 30137581) Nephron. 2017;135(1):1-5. (PMID: 27760424) Korean J Radiol. 2019 Dec;20(12):1597-1615. (PMID: 31854148) J Magn Reson Imaging. 2022 Jul;56(1):45-62. (PMID: 35396897) J Magn Reson Imaging. 2015 Oct;42(4):887-901. (PMID: 25630632) Magn Reson Med. 2005 Nov;54(5):1130-8. (PMID: 16200564) IEEE Trans Med Imaging. 2010 Jan;29(1):196-205. (PMID: 19923044) J Magn Reson Imaging. 2025 Sep;62(3):654-672. (PMID: 40103292) Magn Reson Med. 2014 Sep;72(3):707-17. (PMID: 24142845) IEEE Trans Med Imaging. 2018 Jun;37(6):1310-1321. (PMID: 29870361) Radiology. 1997 Jan;202(1):25-9. (PMID: 8988186) IEEE Trans Med Imaging. 2007 Jan;26(1):68-76. (PMID: 17243585) Magn Reson Med. 2024 May;91(5):1761-1773. (PMID: 37831600) Magn Reson Med. 1992 Jan;23(1):37-45. (PMID: 1734182) J Magn Reson Imaging. 2003 Oct;18(4):404-13. (PMID: 14508776) J Comput Assist Tomogr. 1986 Nov-Dec;10(6):1080-2. (PMID: 3782557) Magn Reson Med. 2007 Dec;58(6):1182-95. (PMID: 17969013) Clin Biochem Rev. 2016 May;37(2):85-98. (PMID: 28303073) Eur Radiol. 2014 Feb;24(2):320-6. (PMID: 24220754) Magn Reson Med. 2024 May;91(5):1743-1760. (PMID: 37876299) Med Image Anal. 1998 Sep;2(3):243-60. (PMID: 9873902) Magn Reson Med. 2001 Nov;46(5):974-84. (PMID: 11675650) IEEE Trans Image Process. 2006 Nov;15(11):3440-51. (PMID: 17076403) IEEE Trans Med Imaging. 2014 Aug;33(8):1581-91. (PMID: 24771574) Diagnostics (Basel). 2018 Jan 05;8(1):. (PMID: 29303965) Invest Radiol. 2013 Jan;48(1):10-6. (PMID: 23192165) Magn Reson Med. 1995 Sep;34(3):293-301. (PMID: 7500865) Magn Reson Med. 1997 Apr;37(4):569-75. (PMID: 9094079) IEEE Trans Med Imaging. 2012 Jun;31(6):1250-62. (PMID: 22345529) Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):212-6. (PMID: 1729691) Magn Reson Med. 2015 Jan;73(1):102-16. (PMID: 24715426) Med Image Anal. 2016 Apr;29:65-78. (PMID: 26802910) MAGMA. 2020 Feb;33(1):141-161. (PMID: 31833014) Nat Rev Nephrol. 2012 Feb 21;8(5):293-300. (PMID: 22349487) J Magn Reson Imaging. 2023 Dec;58(6):1660-1679. (PMID: 37243378) J Magn Reson Imaging. 2021 Apr;53(4):1015-1028. (PMID: 32048372) Radiother Oncol. 2018 Jun;127(3):467-473. (PMID: 29753549) Magn Reson Med. 2022 Sep;88(3):1055-1067. (PMID: 35506512) Magn Reson Med. 2016 Feb;75(2):775-88. (PMID: 25809847) IEEE Trans Image Process. 2004 Apr;13(4):600-12. (PMID: 15376593) Magn Reson Med. 2014 Nov;72(5):1208-17. (PMID: 25216287) Magn Reson Med. 2010 May;63(5):1230-7. (PMID: 20432294) Magn Reson Med. 2005 Dec;54(6):1439-47. (PMID: 16261576) Radiology. 2023 Jan;306(1):47-53. (PMID: 35997609) |
| Grant Information: | W2611103 Key International (Regional) Joint Research Program of the National Natural Science Foundation of China; 82372079 General Program of the National Natural Science Foundation of China; 2024A1515010014 Natural Science Foundation of Guangdong Province; 2023A1515110614 Guangdong Basic and Applied Basic Research Foundation; 2025A1515140128 Guangdong Basic and Applied Basic Research Foundation; 2023B1212120004 Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders |
| Contributed Indexing: | Keywords: MRI; arterial spin labeling; golden‐angle radial sampling; kidney; motion correction; perfusion |
| Substance Nomenclature: | 0 (Spin Labels) |
| Entry Date(s): | Date Created: 20260914 Date Completed: 20260914 Latest Revision: 20260916 |
| Update Code: | 20260916 |
| PubMed Central ID: | PMC13574532 |
| DOI: | 10.1002/nbm.70397 |
| PMID: | 42735918 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1099-1492 |
|---|---|
| DOI: | 10.1002/nbm.70397 |