Academic Journal
Oxygen-to-Sulfur Coordination Switching in Kojic Acid Ligands Tunes the Electronics and Anticancer Activity of Ru(II)-Diphosphine Complexes against Glioblastoma Cells.
| Τίτλος: | Oxygen-to-Sulfur Coordination Switching in Kojic Acid Ligands Tunes the Electronics and Anticancer Activity of Ru(II)-Diphosphine Complexes against Glioblastoma Cells. |
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| Συγγραφείς: | Saha A; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, U.P.208016, India., Singh RR; Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi110016, India.; University of Queensland-IIT Delhi Research Academy, Indian Institute of Technology Delhi, Hauz Khas, New Delhi110016, India., Butcher RJ; Department of Chemistry, Howard University, Washington, District of Columbia20059, United States., Kulshreshtha R; Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi110016, India., Patra AK; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, U.P.208016, India. |
| Πηγή: | Inorganic chemistry [Inorg Chem] 2026 Sep 14; Vol. 65 (36), pp. 20786-20804. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Easton, Pa.] American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Pyrones*/chemistry , Pyrones*/pharmacology , Ruthenium*/chemistry , Ruthenium*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Glioblastoma*/pathology , Glioblastoma*/drug therapy , Phosphines*/chemistry , Phosphines*/pharmacology , Sulfur*/chemistry , Oxygen*/chemistry, Cell Proliferation/drug effects ; Humans ; Ligands ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Molecular Structure ; Models, Molecular ; Crystallography, X-Ray |
| Περίληψη: | Two new ruthenium(II) diphosphine complexes with pyrone and thiopyrone-derived maltol/thiomaltol coordination, [Ru(dppe)2(koj)]PF6 (Ru1) and [Ru(dppe)2(thkoj)]PF6 (Ru2) (dppe = 1,2-bis(diphenylphosphino)ethane; kojH = kojic acid; thkojH = thiokojic acid), were synthesized and thoroughly characterized and found highly active against LN229 and LN18 GBM cancer cell lines by replacement of the coordinated O,O- donor site with an S,O- donor site. Surprisingly, through a series of systematic studies, it was demonstrated that a subtle change in coordination site can have a great impact on the overall electronics of the system, i.e., causing ∼100 nm red shift in MLCT band, ∼150 mV cathodic shift in RuII/RuIII redox potential, and lengthening of the bond length from Ru-O to Ru-S in their corresponding X-ray crystallographic structures, and the results were further validated by DFT studies. Further, such electronic changes of these redox-active compounds have a profound effect on their cytotoxicity against GBM cancer cells. To the best of our knowledge, the synthesis of mononuclear Ru(II)-diphosphine complexes with kojic/thiokojic acid-derived coordination has not been previously reported and tested under in vitro therapeutic activity against GBM cancer cells. This study is among the first to demonstrate that oxidation of the metal center represents the critical activation step that initiates redox homeostasis imbalance, occurring via the formation of a covalent adduct with glutathione. These complexes represent a new design motif for the selective binding of kojic and thiokojic acid in cis-{Ru(dppe)2}-core, and the findings provide the basis for coordination chemistry with this class of ruthenium diphosphine complexes in the realm of biological inorganic chemistry. (© 2026 American Chemical Society.) |
| Grant Information: | EMDR/SG/9/2024-01062 Indian Council of Medical Research; NA University of Queensland; CRG/2021/000527 Science and Engineering Research Board; NA Ministry of Education, India; NA Indian Institute of Technology Delhi |
| Substance Nomenclature: | 0 (Pyrones) 7UI0TKC3U5 (Ruthenium) 0 (Antineoplastic Agents) 0 (Coordination Complexes) 0 (Ligands) 6K23F1TT52 (kojic acid) 0 (Phosphines) 70FD1KFU70 (Sulfur) S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20260914 Date Completed: 20260914 Latest Revision: 20260914 |
| Update Code: | 20260914 |
| DOI: | 10.1021/acs.inorgchem.6c00936 |
| PMID: | 42734383 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1520-510X |
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| DOI: | 10.1021/acs.inorgchem.6c00936 |