Academic Journal
Temporal Variations in Inflammatory-Related Ocular Surface Parameters: A Systematic Review and Meta-Analysis.
| Τίτλος: | Temporal Variations in Inflammatory-Related Ocular Surface Parameters: A Systematic Review and Meta-Analysis. |
|---|---|
| Συγγραφείς: | Wu CY; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia.; Division of Pharmacy and Optometry, The University of Manchester, Manchester, United Kingdom., McGuinness MB; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Makrai E; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia., McMillan P; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia., Kiburg K; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia.; Australian College of Optometry, Melbourne, Victoria, Australia.; National Vision Research Institute, Melbourne, Australia., Singh S; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia., Swiderska K; Division of Pharmacy and Optometry, The University of Manchester, Manchester, United Kingdom., Morgan PB; Division of Pharmacy and Optometry, The University of Manchester, Manchester, United Kingdom., Maldonado-Codina C; Division of Pharmacy and Optometry, The University of Manchester, Manchester, United Kingdom., Chinnery HR; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia., Downie LE; Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia. |
| Πηγή: | Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2026 Sep 01; Vol. 67 (11), pp. 22. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo) Original Publication: St. Louis, Mosby. |
| Ιατρικοί όροι (MeSH): | Tears*/metabolism , Conjunctiva*/metabolism , Cornea*/metabolism , Circadian Rhythm*/physiology , Inflammation*/metabolism, Humans ; Neutrophils ; Leukocyte Count |
| Περίληψη: | Purpose: This systematic review sought to identify, appraise, and synthesize data from studies that investigated inflammatory-related temporal changes, over a 12 ± 4-hour period, in the structure and/or function of ocular surface parameters in healthy individuals. Methods: Comprehensive searches were performed in Ovid MEDLINE and Embase in December 2025. Two authors independently evaluated study eligibility and extracted data. For each parameter, the temporal mean difference (evening minus morning value) was derived. Findings were summarized using narrative syntheses and/or meta-analyses, informed by data availability. Results: Forty-two studies (36 cross-sectional, 2 non-randomized interventional, and 4 randomized controlled trials, n = 706 participants) were included. There was very limited evidence (n = 1 study, narrative findings) relating to temporal variations in human corneal immune cell density. Neutrophil numbers in the palpebral conjunctiva, tear neutrophil gelatinase-associated lipocalin, and tear matrix metalloproteinase-9 levels were generally higher in the morning (n = 1 study, respectively, narrative findings). Meta-analysis suggested tear polymorphonuclear (PMN) leukocyte cell counts may be relatively higher in the morning (2 studies; mean difference: -6,526; 95% confidence interval [CI] = -8362 to -4691 cells, I2 = 0.00%). The certainty of the evidence (Grading of Recommendations, Assessment, Development and Evaluation [GRADE]) was judged as very low for all outcomes, due to risk-of-bias, insufficient studies, and/or low sample sizes. Conclusions: Further to the availability of very low certainty evidence, it remains unclear whether the ocular surface inflammatory status in healthy individuals differs in the morning relative to the evening. Further research is required to understand the extent to which temporal factors affect the homeostasis of inflammatory-related ocular surface parameters in healthy individuals. |
| References: | Microvasc Res. 2015 Sep;101:15-9. (PMID: 26092682) Graefes Arch Clin Exp Ophthalmol. 2010 Jun;248(6):853-62. (PMID: 20127108) Curr Eye Res. 1993 Nov;12(11):1001-7. (PMID: 8306709) Cornea. 2010 Jan;29(1):34-8. (PMID: 19907294) Am J Ophthalmol. 1999 Feb;127(2):153-7. (PMID: 10030556) Clin Exp Optom. 2017 Jan;100(1):33-40. (PMID: 27353750) Cont Lens Anterior Eye. 2013 Jun;36(3):140-5. (PMID: 23290099) Clin Exp Optom. 2011 Nov;94(6):557-62. (PMID: 21883458) J Clin Epidemiol. 2019 Jul;111:105-114. (PMID: 29432858) Ocul Surf. 2023 Jul;29:1-52. (PMID: 37062427) Cont Lens Anterior Eye. 2006 Mar;29(1):25-30. (PMID: 16448840) Ophthalmology. 2008 Nov;115(11):1982-8. (PMID: 18708259) JAMA Ophthalmol. 2015 Dec;133(12):1480. (PMID: 26469931) Dtsch Arztebl Int. 2015 Jan 30;112(5):71-81; quiz 82. (PMID: 25686388) Nat Rev Immunol. 2024 Dec;24(12):896-911. (PMID: 39215057) Eye Contact Lens. 2012 May;38(3):146-9. (PMID: 22415150) Can J Physiol Pharmacol. 2002 Oct;80(10):935-40. (PMID: 12450059) Invest Ophthalmol Vis Sci. 2014 May 15;55(6):3525-31. (PMID: 24833736) Int J Epidemiol. 2008 Oct;37(5):1158-60. (PMID: 18832388) Adv Ther. 2018 Nov;35(11):1775-1804. (PMID: 30341506) Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1479-84. (PMID: 22323468) Optom Vis Sci. 2007 Jun;84(6):511-6. (PMID: 17568321) Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13093-8. (PMID: 26392540) Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2217795120. (PMID: 37487076) Ocul Surf. 2023 Apr;28:213-252. (PMID: 37062428) Curr Eye Res. 1992 Mar;11(3):243-51. (PMID: 1534045) Gastro Hep Adv. 2022 Feb 03;1(1):93-105. (PMID: 39129932) Optom Vis Sci. 2014 Dec;91(12):1391-5. (PMID: 25325761) Optom Vis Sci. 2016 Aug;93(8):820-7. (PMID: 27362615) Optom Vis Sci. 2018 Dec;95(12):1088-1095. (PMID: 30451803) Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):85-8. (PMID: 12605260) Sci Rep. 2024 Mar 25;14(1):7061. (PMID: 38528025) Br J Ophthalmol. 1986 Apr;70(4):246-8. (PMID: 3083863) Ann Clin Biochem. 2017 Sep;54(5):521-529. (PMID: 28193107) Sci Transl Med. 2016 Feb 3;8(324):324ra16. (PMID: 26843191) PLoS One. 2017 Sep 21;12(9):e0184790. (PMID: 28934261) J Leukoc Biol. 2019 Jun;105(6):1087-1098. (PMID: 30977943) Nature. 2008 Jul 24;454(7203):428-35. (PMID: 18650913) Ocul Surf. 2020 Jan;18(1):56-63. (PMID: 31563549) PLoS One. 2015 Aug 12;10(8):e0135323. (PMID: 26267853) Cornea. 2008 Aug;27(7):758-63. (PMID: 18650659) Arch Ophthalmol. 1973 Aug;90(2):94-6. (PMID: 4721213) Int J Mol Sci. 2021 Nov 15;22(22):. (PMID: 34830212) Eye Contact Lens. 2012 Sep;38(5):282-7. (PMID: 22868900) Graefes Arch Clin Exp Ophthalmol. 2001 Apr;239(4):257-63. (PMID: 11450489) Curr Eye Res. 2011 Mar;36(3):198-207. (PMID: 21275520) Exp Eye Res. 1984 Jan;38(1):15-26. (PMID: 6538509) Eye Contact Lens. 2010 Mar;36(2):96-100. (PMID: 20145542) Ophthalmic Physiol Opt. 1982;2(3):187-91. (PMID: 7177644) Clin Exp Optom. 2016 Mar;99(2):142-8. (PMID: 27012691) BMJ. 2016 Oct 12;355:i4919. (PMID: 27733354) Ophthalmologica. 1999;213(6):345-9. (PMID: 10567864) Trans Am Ophthalmol Soc. 1991;89:209-13; discussion 213-4. (PMID: 1808807) Science. 2002 Feb 8;295(5557):1070-3. (PMID: 11834835) Cont Lens Anterior Eye. 2021 Feb;44(1):14-17. (PMID: 32873461) Curr Eye Res. 2022 Sep;47(9):1239-1245. (PMID: 35726825) Cont Lens Anterior Eye. 2025 Jul;48(4):102388. (PMID: 40102139) Ophthalmic Physiol Opt. 2023 Mar;43(2):273-283. (PMID: 36592129) Front Immunol. 2019 May 31;10:1178. (PMID: 31231369) Cornea. 1992 Mar;11(2):114-20. (PMID: 1582213) Eur J Ophthalmol. 2012;22 Suppl 7:S1-4. (PMID: 22180151) Ophthalmic Physiol Opt. 1984;4(4):355-7. (PMID: 6542197) Cornea. 2016 Aug;35(8):1104-11. (PMID: 27261939) BMJ. 2019 Aug 28;366:l4898. (PMID: 31462531) Eye Contact Lens. 2019 May;45(3):171-181. (PMID: 30303825) Cont Lens Anterior Eye. 2023 Dec;46(6):102060. (PMID: 37714745) Ann Ophthalmol. 1978 Jan;10(1):75-80. (PMID: 565184) Alcohol Res Health. 2001;25(2):85-93. (PMID: 11584554) Ophthalmology. 2022 Oct;129(10):1192-1215. (PMID: 35597519) J Clin Invest. 2002 Oct;110(8):1105-11. (PMID: 12393846) Ophthalmic Physiol Opt. 2024 Nov;44(7):1524-1529. (PMID: 39161278) Eye Contact Lens. 2010 May;36(3):156-63. (PMID: 20395868) Front Immunol. 2016 Dec 09;7:583. (PMID: 28018350) Cytokine. 2006 Jan 7;33(1):36-40. (PMID: 16406556) BMC Ophthalmol. 2023 Jul 28;23(1):338. (PMID: 37507767) J Biol Rhythms. 2015 Aug;30(4):277-90. (PMID: 25900041) BMJ. 2014 Sep 24;349:g5630. (PMID: 25252733) Eur J Ophthalmol. 2013 Sep-Oct;23(5):641-5. (PMID: 23516251) J Clin Immunol. 1998 Jan;18(1):61-70. (PMID: 9475355) Ophthalmology. 2008 Aug;115(8):1279-85. (PMID: 18294691) Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2237-2247. (PMID: 31112608) Ann Rheum Dis. 1997 Jan;56(1):27-31. (PMID: 9059137) Ann Rheum Dis. 2013 Feb;72(2):204-10. (PMID: 22562974) Cornea. 2010 Jun;29(6):607-12. (PMID: 20458235) Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):1. (PMID: 32870244) Cont Lens Anterior Eye. 2016 Aug;39(4):307-10. (PMID: 26923921) Ocul Surf. 2020 Oct;18(4):770-776. (PMID: 32828970) JAMA Ophthalmol. 2020 Jan 1;138(1):58-68. (PMID: 31774457) Ophthalmic Physiol Opt. 2016 Nov;36(6):643-648. (PMID: 27790772) Surv Ophthalmol. 2020 Mar - Apr;65(2):171-186. (PMID: 31628907) Lancet. 2008 Jan 19;371(9608):205-14. (PMID: 18207016) J Glaucoma. 2003 Jun;12(3):232-6. (PMID: 12782841) Ocul Surf. 2019 Jan;17(1):89-97. (PMID: 30321605) Am J Optom Physiol Opt. 1988 Mar;65(3):151-4. (PMID: 3364523) Cornea. 2000 Nov;19(6):824-32. (PMID: 11095058) Clin Transl Med. 2024 Nov;14(11):e1762. (PMID: 39496510) Biochem Biophys Res Commun. 2021 Nov 19;579:161-167. (PMID: 34601201) Acta Ophthalmol (Copenh). 1986 Apr;64(2):216-20. (PMID: 3727963) Cornea. 2013 Oct;32(10):1305-10. (PMID: 23974881) Optom Vis Sci. 2011 Dec;88(12):1433-8. (PMID: 21892112) Cornea. 2015 Jul;34(7):808-16. (PMID: 25933399) BMJ. 2003 Sep 6;327(7414):557-60. (PMID: 12958120) |
| Entry Date(s): | Date Created: 20260914 Date Completed: 20260914 Latest Revision: 20260921 |
| Update Code: | 20260921 |
| PubMed Central ID: | PMC13589403 |
| DOI: | 10.1167/iovs.67.11.22 |
| PMID: | 42734307 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1552-5783 |
|---|---|
| DOI: | 10.1167/iovs.67.11.22 |