Academic Journal
Ultrasound-assisted extraction of polyphenols from Moutan Cortex using natural deep eutectic solvent: Optimization, molecular mechanisms, and lipid-lowering activity.
| Τίτλος: | Ultrasound-assisted extraction of polyphenols from Moutan Cortex using natural deep eutectic solvent: Optimization, molecular mechanisms, and lipid-lowering activity. |
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| Συγγραφείς: | Yin S; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China., Peng W; School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR China., Wang Y; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China., Lu H; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China., Liu P; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China., Zhu X; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China., Yang H; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China., Li J; School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, PR China. Electronic address: jgli@yzu.edu.cn., Li L; Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China. Electronic address: liliuhui01@163.com. |
| Πηγή: | Ultrasonics sonochemistry [Ultrason Sonochem] 2026 Oct; Vol. 133, pp. 108052. Date of Electronic Publication: 2026 Sep 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9433356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2828 (Electronic) Linking ISSN: 13504177 NLM ISO Abbreviation: Ultrason Sonochem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Science Original Publication: Oxford : Butterworth Heinemann, c1994- |
| Ιατρικοί όροι (MeSH): | Polyphenols*/isolation & purification , Polyphenols*/pharmacology , Polyphenols*/chemistry , Paeonia*/chemistry , Chemical Fractionation*/methods , Deep Eutectic Solvents*/chemistry , Drugs, Chinese Herbal*/chemistry , Ultrasonic Waves*, Solvents/chemistry ; Molecular Dynamics Simulation ; Animals |
| Περίληψη: | Moutan Cortex is a valuable medicinal resource rich in bioactive polyphenols, yet its sustainable valorization is often hindered by the inefficiencies and environmental concerns associated with conventional extraction methods. In this study, a green and efficient ultrasound-assisted extraction (UAE) strategy was developed using a betaine-levulinic acid (Bet-LevA) natural deep eutectic solvent (NADES). An intelligent optimization approach was applied to determine the optimal extraction conditions, achieving a maximum total polyphenol content of 27.03 ± 0.41 mg GAE/g DW, which was 1.93-fold higher than that obtained using 70% ethanol extraction. The molecular mechanisms underlying the superior extraction performance of Bet-LevA were further elucidated using FT-IR, conductor-like screening model for realistic solvents (COSMO-RS), and molecular dynamics (MD) simulations, revealing that hydrogen-bond networks and stronger solvent-polyphenol interactions promoted solubilization and stabilization of phenolic compounds. Furthermore, the extracted polyphenol fraction effectively alleviated fatty acid-induced lipid accumulation in AML-12 hepatocytes. Overall, this study provides a sustainable extraction framework integrating green solvent design, intelligent optimization, molecular mechanism analysis, and functional evaluation for the high-value utilization of Moutan Cortex in functional foods and nutraceutical applications. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: COSMO-RS; Lipid-lowering activity; Molecular dynamics simulation; MoutanCortex; Natural deep eutectic solvents; Polyphenols; Ultrasound-assisted extraction |
| Substance Nomenclature: | 0 (Polyphenols) 0 (moutan cortex) 0 (Deep Eutectic Solvents) 0 (Drugs, Chinese Herbal) 0 (Solvents) |
| Entry Date(s): | Date Created: 20260912 Date Completed: 20261005 Latest Revision: 20261005 |
| Update Code: | 20261006 |
| PubMed Central ID: | PMC13587915 |
| DOI: | 10.1016/j.ultsonch.2026.108052 |
| PMID: | 42731572 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-2828 |
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| DOI: | 10.1016/j.ultsonch.2026.108052 |