Academic Journal
Προβολή σε EDS

Conjunctival biopsy findings associated with fibrosis and sequelae in ocular Mucous membrane pemphigoid.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Conjunctival biopsy findings associated with fibrosis and sequelae in ocular Mucous membrane pemphigoid.
Συγγραφείς: Ringer A; Clínica y Laboratorio Inmunológico Especializado CM/LABI, Rosario, Santa Fe, Argentina.; Instituto de Inmunología Clínica y Experimental de Rosario (IDICER-CONICET-UNR), Rosario, Santa Fe, Argentina.; Facultad de Medicina, Universidad Nacional de Rosario, Santa Fe, Argentina., Smichowski A; Consultorio Privado de Reumatología Vicente López, Buenos Aires, Argentina., Siegrist CN; Clínica y Laboratorio Inmunológico Especializado CM/LABI, Rosario, Santa Fe, Argentina., Grossi GD; Grupo Oftalmológico Alfa, Rosario, Santa Fe, Argentina., Gómez RA; Hospital Universitario Austral, Buenos Aires, Argentina., Zarate JO; Laboratorio de Patología Digital, Universidad Maimónides, Buenos Aires, Argentina.; Laboratorio de Investigaciones y Ciencias Visuales, Facultad de Medicina, Universidad De Buenos Aires, Buenos Aires, Argentina., Rosa JE; Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina., Brance ML; Facultad de Medicina, Universidad Nacional de Rosario, Santa Fe, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario, Santa Fe, Argentina., Pérez AR; Instituto de Inmunología Clínica y Experimental de Rosario (IDICER-CONICET-UNR), Rosario, Santa Fe, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario, Santa Fe, Argentina., Gandino IJ; Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. ignaciojgandino@gmail.com.; Hospital de Agudos Juan Antonio Fernández, Ciudad Autónoma de Buenos Aires, Argentina. ignaciojgandino@gmail.com.
Πηγή: International ophthalmology [Int Ophthalmol] 2026 Sep 11; Vol. 46 (1). Date of Electronic Publication: 2026 Sep 11.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE
Imprint Name(s): Publication: Dordrecht : Kluwer
Original Publication: The Hague, Junk.
Ιατρικοί όροι (MeSH): Pemphigoid, Benign Mucous Membrane*/pathology , Pemphigoid, Benign Mucous Membrane*/complications , Pemphigoid, Benign Mucous Membrane*/diagnosis , Conjunctiva*/pathology, Fibrosis/etiology ; Fibrosis/pathology ; Humans ; Female ; Male ; Biopsy ; Middle Aged ; Follow-Up Studies ; Retrospective Studies ; Aged
Περίληψη: Purpose: Ocular mucous membrane pemphigoid (OcMMP) leads to fibrosis of the conjunctiva with potential sequelae. Our objective was to describe biopsies from patients with OcMMP and identify biopsy characteristics associated with fibrosis and sequelae.
Methods: Patients with histologically confirmed OcMMP were selected. Fibrosis grades were defined according to Foster's stages. The subjects were divided into two groups: early stages (0 and 1) versus later stages (2, 3, and 4). A Cox multivariate analysis was performed to determine whether immunofluorescence deposits were associated with sequelae.
Results: Fifty-seven patients were included. The mean age at diagnosis was 62.7 (SD 13.2) years, and 41 (71.9%) were women. The follow-up time was 1.5 years (IQR 0.3-3). Patients with early Foster were 50.9%. The presence of mast cells was associated with early stages, whereas eosinophils were associated with later stages at the time of diagnosis. In the multivariate Cox regression analysis, the presence of IgA deposits was associated with developing sequelae (HR 10.8; IC 95% 1.3-92.9; p 0.03).
Conclusion: Eosinophils were more frequently observed in patients with advanced Foster stages, and IgA was associated with the sequelae.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Conflicts of interest: Andrea Smichowski is employee of Janssen. All other authors have no relevant financial or non-financial interests to disclose.
References: Blood. 2022 Dec 29;140(26):2805-2817. (PMID: 36283106)
Eye (Lond). 2017 Feb;31(2):301-332. (PMID: 28106896)
Am J Ophthalmol. 1978 Aug;86(2):250-9. (PMID: 686127)
Annu Rev Immunol. 2020 Apr 26;38:49-77. (PMID: 32340580)
Am J Ophthalmol. 2020 Aug;216:1-6. (PMID: 32067959)
Cornea. 2019 Nov;38(11):1406-1411. (PMID: 31356420)
Trans Am Ophthalmol Soc. 1986;84:527-663. (PMID: 3296406)
Toxicol Pathol. 2021 Apr;49(3):472-482. (PMID: 33252012)
Cornea. 2023 Dec 1;42(12):1503-1505. (PMID: 36728301)
Cornea. 2024 Feb 1;43(2):159-165. (PMID: 37699562)
Arch Dermatol. 2002 Mar;138(3):370-9. (PMID: 11902988)
J Eur Acad Dermatol Venereol. 2021 Oct;35(10):1926-1948. (PMID: 34309078)
Eye (Lond). 2012 Sep;26(9):1199-208. (PMID: 22722485)
Immunology. 2022 Dec;167(4):590-605. (PMID: 36054617)
Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):17. (PMID: 38095906)
Circulation. 2011 Nov 8;124(19):2106-16. (PMID: 22025605)
Drugs. 2005;65(13):1767-79. (PMID: 16114976)
Semin Ophthalmol. 2011 Jul-Sep;26(4-5):270-7. (PMID: 21958173)
Wound Repair Regen. 2019 Jan;27(1):19-28. (PMID: 30368969)
Clin Exp Immunol. 2015 Aug;181(2):357-61. (PMID: 25845491)
Prog Retin Eye Res. 2004 Nov;23(6):579-92. (PMID: 15388075)
Ophthalmology. 1981 Feb;88(2):95-100. (PMID: 7015218)
J Appl Lab Med. 2022 Jan 5;7(1):165-196. (PMID: 34996089)
Exp Ther Med. 2020 Oct;20(4):3379-3382. (PMID: 32905166)
Immunol Rev. 2018 Mar;282(1):188-197. (PMID: 29431211)
Allergy Asthma Proc. 2004 Jan-Feb;25(1):33-6. (PMID: 15055560)
Front Med (Lausanne). 2023 Nov 08;10:1257288. (PMID: 38020098)
Am J Ophthalmol. 1983 Oct;96(4):453-9. (PMID: 6353928)
Allergy. 2024 Dec;79(12):3192-3237. (PMID: 39370939)
Eye (Lond). 2018 Oct;32(10):1636-1643. (PMID: 29921954)
Am J Pathol. 2011 Aug;179(2):795-806. (PMID: 21718682)
Cornea. 2018 Apr;37(4):436-441. (PMID: 29341971)
Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3417-23. (PMID: 12882790)
Br J Dermatol. 1998 Apr;138(4):602-10. (PMID: 9640363)
Clin Exp Immunol. 2020 Mar;199(3):326-336. (PMID: 31660581)
J Eur Acad Dermatol Venereol. 2021 Sep;35(9):1750-1764. (PMID: 34245180)
JAMA Dermatol. 2023 Feb 1;159(2):198-203. (PMID: 36630148)
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2322-9. (PMID: 18515578)
Ocul Surf. 2023 Oct;30:142-149. (PMID: 37690517)
Ocul Immunol Inflamm. 2021 Aug 18;29(6):1106-1113. (PMID: 32130051)
Ophthalmology. 2018 Apr;125(4):496-504. (PMID: 29217149)
Contributed Indexing: Keywords: Biopsy; Fibrosis; Histology; Ocular Cicatricial Pemphigoid; Sequelae
Entry Date(s): Date Created: 20260911 Date Completed: 20260911 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1007/s10792-026-04273-7
PMID: 42726336
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-2630
DOI:10.1007/s10792-026-04273-7