Academic Journal
Evaluation of the NIH Toolbox Odor Identification Test in African American older adults with and without amnestic mild cognitive impairment.
| Title: | Evaluation of the NIH Toolbox Odor Identification Test in African American older adults with and without amnestic mild cognitive impairment. |
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| Authors: | Ece B; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Giordani B; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Goldstein F; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Weintraub S; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Manly J; Department of Neurology, Columbia University, New York, NY, USA., Dalton P; Monell Chemical Senses Center, Philadelphia, PA, USA., Parma V; Monell Chemical Senses Center, Philadelphia, PA, USA.; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gershon RC; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Ho EH; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
| Source: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2026 Oct; Vol. 113 (4), pp. 1886-1894. Date of Electronic Publication: 2026 Sep 11. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Thousand Oaks, CA] : SAGE Publications Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| MeSH Terms: | Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/psychology , Amnesia*/diagnosis , Smell*/physiology , Black or African American* , Odorants*, Humans ; Female ; Male ; Aged ; United States ; ROC Curve ; National Institutes of Health (U.S.) ; Aged, 80 and over ; Sensitivity and Specificity ; Aging |
| Abstract: | BackgroundEarly detection of amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer's disease (AD), is critical for timely intervention. Declines in olfactory function seem to be a promising, non-invasive indicator of AD pathology, but screening research in underrepresented groups is limited.ObjectiveTo evaluate the diagnostic discrimination and exploratory utility of the NIH Toolbox Odor Identification Test (NIHTB-OIT) in distinguishing healthy aging from aMCI in older African American adults.MethodsParticipants included 93 healthy agers (81.7% female; M |
| Competing Interests: | Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Contributed Indexing: | Keywords: African Americans; Alzheimer's disease; NIH Toolbox Odor Identification Test; aging; amnestic mild cognitive impairment; biomarkers; olfaction |
| Entry Date(s): | Date Created: 20260911 Date Completed: 20261013 Latest Revision: 20261014 |
| Update Code: | 20261015 |
| DOI: | 10.1177/13872877261483176 |
| PMID: | 42725855 |
| Database: | MEDLINE |
| ISSN: | 1875-8908 |
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| DOI: | 10.1177/13872877261483176 |