Academic Journal
A histone H2A docking domain mutant interferes with proper yFACT-gene interactions in Saccharomyces cerevisiae.
| Τίτλος: | A histone H2A docking domain mutant interferes with proper yFACT-gene interactions in Saccharomyces cerevisiae. |
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| Συγγραφείς: | Joseph L; Biology Department, Hendrix College, Conway, AR, United States., Ozersky SA; Biology Department, Hendrix College, Conway, AR, United States., Tucker MG; Biology Department, Hendrix College, Conway, AR, United States., Turner GA; Biology Department, Hendrix College, Conway, AR, United States., Edwards MJ; Biology Department, Hendrix College, Conway, AR, United States., Huynh ML; Biology Department, Hendrix College, Conway, AR, United States., Duina AA; Biology Department, Hendrix College, Conway, AR, United States. |
| Πηγή: | MicroPublication biology [MicroPubl Biol] 2026 Aug 25; Vol. 2026. Date of Electronic Publication: 2026 Aug 25 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Caltech Library Country of Publication: United States NLM ID: 101759238 Publication Model: eCollection Cited Medium: Internet ISSN: 2578-9430 (Electronic) Linking ISSN: 25789430 NLM ISO Abbreviation: MicroPubl Biol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Pasadena, CA : Caltech Library, [2016]- |
| Περίληψη: | Alterations within the nucleosomal Influences Spt16-Gene Interactions (ISGI) region, which is located on the side of the nucleosome and is comprised of histone H3 and H4 residues, shift yFACT occupancy toward the 3' ends of genes, likely due to defective yFACT dissociation following transcription. Here, we show that a single amino acid substitution within the histone H2A docking domain, H2A-I103A, similarly alters yFACT-gene interactions. These results demonstrate that histone H2A integrity is required for proper yFACT-gene interactions in vivo and suggest that the H2A docking domain promotes yFACT dissociation from genes. (Copyright: © 2026 by the authors.) |
| Competing Interests: | The authors declare that there are no conflicts of interest present. |
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| Grant Information: | P20 GM103429 United States GM NIGMS NIH HHS |
| Entry Date(s): | Date Created: 20260910 Date Completed: 20260910 Latest Revision: 20260912 |
| Update Code: | 20260912 |
| PubMed Central ID: | PMC13555346 |
| DOI: | 10.17912/micropub.biology.002322 |
| PMID: | 42719597 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2578-9430 |
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| DOI: | 10.17912/micropub.biology.002322 |