Academic Journal
The parcellation organization of cerebellum associated with white-matter functional systems.
| Τίτλος: | The parcellation organization of cerebellum associated with white-matter functional systems. |
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| Συγγραφείς: | Wang P; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China. Electronic address: wpjoepan@163.com., Mao Y; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China., Qian L; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China., Xue M; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, China., Tang Q; Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China. Electronic address: tangqin0201@163.com., Biswal BB; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA. Electronic address: bbiswal@gmail.com. |
| Πηγή: | NeuroImage [Neuroimage] 2026 Oct 15; Vol. 340, pp. 122209. Date of Electronic Publication: 2026 Sep 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Orlando, FL : Academic Press, c1992- |
| Ιατρικοί όροι (MeSH): | Cerebellum*/physiology , Cerebellum*/anatomy & histology , Cerebellum*/diagnostic imaging , White Matter*/physiology , White Matter*/diagnostic imaging , White Matter*/anatomy & histology , Connectome*/methods , Gray Matter*/physiology , Gray Matter*/diagnostic imaging , Gray Matter*/anatomy & histology , Nerve Net*/physiology , Nerve Net*/diagnostic imaging, Magnetic Resonance Imaging/methods ; Neural Pathways/physiology ; Neural Pathways/anatomy & histology ; Image Processing, Computer-Assisted/methods ; Humans ; Male ; Female ; Adult |
| Περίληψη: | The cerebellar role in various cognitive functions other than motor coordination has been gradually recognized, while its functional architecture and interaction with white matter functional networks (WM-FNs) remain unclear. The study combined resting-state functional connectivity and K-means clustering methods to obtain nine WM-FNs and seven gray matter functional networks (GM-FNs) by using the test-retest neuroimaging dataset collected from human connectome project. Subsequently, adopting winner-take-all algorithm and two distinct connectivity-based parcellations, we identified two parcellation maps of the cerebellum that corresponded to WM- and GM-FNs, respectively. We observed the cerebellar parcellations with unique spatial distribution pattern, which corresponds to white matter and gray matter functional systems. Additionally, the distinct WM-FNs exhibited high functional connectivity with GM-FNs, which corresponded to the overlapping maps between their cerebellar sub-regions well, indicating that intrinsic functional connectivity has an important constraint on the topological structure of cerebellum. Our finding created a new cerebellar parcellation atlas, advancing the mechanisms' understanding of interaction between cerebellar organization and functional systems. (Copyright © 2026. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest The authors declare no competing interests. |
| Contributed Indexing: | Keywords: Cerebellum; Functional connectivity; Motor coordination; Parcellation map; White matter functional networks |
| Entry Date(s): | Date Created: 20260908 Date Completed: 20260929 Latest Revision: 20260929 |
| Update Code: | 20260930 |
| DOI: | 10.1016/j.neuroimage.2026.122209 |
| PMID: | 42710645 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1095-9572 |
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| DOI: | 10.1016/j.neuroimage.2026.122209 |