Academic Journal
Atomistic TCR-pMHC interactions bias CD8 memory fate within a single antigen-specific repertoire.
| Τίτλος: | Atomistic TCR-pMHC interactions bias CD8 memory fate within a single antigen-specific repertoire. |
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| Συγγραφείς: | Akitsu A; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Tan K; Structural Biology Center, X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, IL 60439, USA., Mallis RJ; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Duke-Cohan JS; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Brazin KN; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Kirkpatrick EH; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA., Parkins AN; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Seabury AG; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA., Aryal S; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Cinella V; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Lee JJ; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Uberoy KI; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Koenig JK; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Biddle M; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Messier CM; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Lizotte PH; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Hwang W; Departments of Biomedical Engineering, Materials Science & Engineering, Physics & Astronomy, Texas A&M University, College Station, TX 77843, USA; Center for AI and Natural Sciences, Korea Institute for Advanced Study, Seoul 02455, Republic of Korea., Lang MJ; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: matt.lang@vanderbilt.edu., Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ellis_reinherz@dfci.harvard.edu. |
| Πηγή: | Cell reports [Cell Rep] 2026 Sep 22; Vol. 45 (9), pp. 117908. Date of Electronic Publication: 2026 Sep 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| Ιατρικοί όροι (MeSH): | CD8-Positive T-Lymphocytes*/immunology , Immunologic Memory*/immunology , Receptors, Antigen, T-Cell, alpha-beta*/metabolism , Receptors, Antigen, T-Cell, alpha-beta*/immunology , Receptors, Antigen, T-Cell, alpha-beta*/chemistry , Receptors, Antigen, T-Cell*/metabolism, Animals ; Mice ; Mice, Inbred C57BL |
| Περίληψη: | Memory CD8 T cells provide durable protection against recurrent infection and cancer, but how individual TCR clonotypes contribute to distinct memory fates remains enigmatic. Here, we analyzed 242 murine CD8 TCRαβ clonotypes specific for an influenza NP (Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interests Authors declare that they have no competing interests. |
| Contributed Indexing: | Keywords: CD3 ITAM phosphorylation; CP: immunology; T-cell memory differentiation; T-cell repertoires; Vα vs. Vβ polarity; heterosubtypic crossreactivity; mechanochemistry; mechanophore; mechanotransduction; pMHC recognition; structural immunology |
| Substance Nomenclature: | 0 (Receptors, Antigen, T-Cell, alpha-beta) 0 (Receptors, Antigen, T-Cell) |
| Entry Date(s): | Date Created: 20260908 Date Completed: 20260924 Latest Revision: 20260924 |
| Update Code: | 20260924 |
| DOI: | 10.1016/j.celrep.2026.117908 |
| PMID: | 42709546 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2026.117908 |