Academic Journal
Extraction and Isolation of Bioactive Compounds From Malpighia glabra L. Leaves: In Vivo Investigation of the Leaf Extract Against Oxidative Stress and Inflammation Triggered by γ-Radiation.
| Τίτλος: | Extraction and Isolation of Bioactive Compounds From Malpighia glabra L. Leaves: In Vivo Investigation of the Leaf Extract Against Oxidative Stress and Inflammation Triggered by γ-Radiation. |
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| Συγγραφείς: | Fekry AM; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., El-Sabbagh WA; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Bakr MSA; Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al Azhar University, Cairo, Egypt., Mohammed AEI; Department of Pharmacognosy, Faculty of Pharmacy (Boys), Al Azhar University, Cairo, Egypt., El-Ghazaly MA; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. |
| Πηγή: | Chemistry & biodiversity [Chem Biodivers] 2026 Sep; Vol. 23 (9), pp. e71636. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| Ιατρικοί όροι (MeSH): | Oxidative Stress*/drug effects , Oxidative Stress*/radiation effects , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Gamma Rays*/adverse effects , Inflammation*/drug therapy , Malpighiaceae*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/isolation & purification , Anti-Inflammatory Agents*/chemistry, Plant Leaves/chemistry ; Antioxidants/pharmacology ; Antioxidants/isolation & purification ; Antioxidants/chemistry ; NF-kappa B/metabolism ; Animals ; Rats ; Male |
| Περίληψη: | Malpighia glabra L. (Acerola), belonging to the family Malpighiaceae, is highly rich in phenolics, flavonoids and ascorbic acid content, which are collectively recognized for their potent antioxidant and anti-inflammatory activities. Since ionizing radiation harm is primarily driven by excessive reactive oxygen species generation and persistent inflammation, this study aimed to explore the radioprotective potential of Malpighia glabra leaf extract (MLE) and identify its bioactive constituents. β-isoarborinol, afzelechin, engeletin, and flavonoid glycosides had been isolated from the ethyl acetate fraction, and their structures were assigned based on NMR/MS data. Histopathological examination revealed that MLE treatment attenuated radiation-induced histopathological alterations in multiple organs of irradiated rats. The anti-inflammatory activity of MLE was elucidated by suppression of the intestinal NF-κB/TNF-α signaling cascade, along with systemic suppression of serum TNF-α (>70%) and CRP (>25%). MLE restored redox homeostasis by normalizing GSH, TBARs and TAC levels, ultimately preserving hepatic and renal functions. Otherwise, MLE exhibited modest protective effects on haematological parameters, accompanied by dose-dependent preservation of body weight. These findings identify MLE as a promising natural radioprotective agent and provide a mechanistic basis for its further development as an adjunct strategy to reduce radiation-induced systemic and tissue alterations in a dose-dependent manner. (© 2026 The Author(s). Chemistry & Biodiversity published by Wiley‐VHCA AG.) |
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| Contributed Indexing: | Keywords: Malphigia glabra L.; antioxidant; anti‐inflammatory; γ‐radiation |
| Substance Nomenclature: | 0 (Plant Extracts) 0 (Antioxidants) 0 (Anti-Inflammatory Agents) 0 (NF-kappa B) |
| Entry Date(s): | Date Created: 20260908 Date Completed: 20260908 Latest Revision: 20260910 |
| Update Code: | 20260910 |
| PubMed Central ID: | PMC13551133 |
| DOI: | 10.1002/cbdv.71636 |
| PMID: | 42707041 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1612-1880 |
|---|---|
| DOI: | 10.1002/cbdv.71636 |