Academic Journal
Narrowband isotropic magnetic particle imaging with FFL-parallel excitation.
| Τίτλος: | Narrowband isotropic magnetic particle imaging with FFL-parallel excitation. |
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| Συγγραφείς: | Bian Z; School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China.; Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing 100191, People's Republic of China., Chen Z; School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China.; Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing 100191, People's Republic of China., He J; School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China.; Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing 100191, People's Republic of China., Hui H; CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Jia G; School of Computer Science and Technology, Xidian University, Xi'an, Shaanxi 710071, People's Republic of China., An Y; School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China.; Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing 100191, People's Republic of China., Tian J; School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China.; Key Laboratory of Big Data-Based Precision Medicine of Ministry of Industry and Information Technology, School of Engineering Medicine, Beihang University, Beijing 100191, People's Republic of China.; CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.; National Key Laboratory of Kidney Diseases, Beijing 100853, People's Republic of China. |
| Πηγή: | Physics in medicine and biology [Phys Med Biol] 2026 Oct 08; Vol. 71 (19). Date of Electronic Publication: 2026 Oct 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bristol : IOP Publishing |
| Ιατρικοί όροι (MeSH): | Magnetic Particle Imaging*/methods , Magnetic Particle Imaging*/instrumentation, Signal-To-Noise Ratio ; Anisotropy ; Phantoms, Imaging ; Image Processing, Computer-Assisted |
| Περίληψη: | Objective.Magnetic particle imaging (MPI) is an emerging medical imaging technique for high-sensitivity and quantitative visualization of tracer distributions. Narrowband MPI achieves high signal-to-noise ratio (SNR) by selectively detecting a few harmonics. However, in its conventional implementations,the point spread function (PSF) inevitably exhibits negative lobes, which introduce anisotropic resolution and destructive signal superposition.Approach.To address this, we propose a narrowband isotropic MPI system, utilizing the field-free-line (FFL)-parallel excitation (FPE) scanning strategy to eliminate negative lobes. FPE-MPI employs single-channel acquisition with coaxial excitation and receive, applies an excitation field parallel to the FFL while maintaining a constant collinear offset field, and encodes harmonic responses on the projection plane orthogonal to the FFL.Main results.Through simulations and phantom experiments on our in-house scanner, we demonstrate that FPE-MPI eliminates the adverse effects of negative lobes, achieves isotropic imaging, and improves image quality. Compared with conventional narrowband MPI with FFL-orthogonal excitation, FPE-MPI preserves higher SNR in the acquired signals and yields robust reconstructions at low tracer concentrations, with only a modest trade-off in spatial resolution.Significance.FPE-MPI facilitates robust imaging at low tracer doses and provides a feasible scanning strategy for the development of future large field-of-view (FOV) narrowband MPI systems. (© 2026 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.) |
| Contributed Indexing: | Keywords: field-free-line; isotropic imaging; magnetic particle imaging; narrowband; parallel excitation |
| Entry Date(s): | Date Created: 20260907 Date Completed: 20261008 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1088/1361-6560/aea399 |
| PMID: | 42705321 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1361-6560 |
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| DOI: | 10.1088/1361-6560/aea399 |